publication . Other literature type . Article . 2006

Increased seizure duration and slowed potassium kinetics in mice lacking aquaporin-4 water channels

Thomas J. Sick; Xiaoming Yao; Geoffrey T. Manley; Zsolt Zador; Alan S. Verkman; Devin K. Binder;
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  • Published: 15 Apr 2006
  • Publisher: Wiley
Abstract
The glial water channel aquaporin-4 (AQP4) has been hypothesized to modulate water and potassium fluxes associated with neuronal activity. In this study, we examined the seizure phenotype of AQP4 -/- mice using in vivo electrical stimulation and electroencephalographic (EEG) recording. AQP4 -/- mice were found to have dramatically prolonged stimulation-evoked seizures after hippocampal stimulation compared to wild-type controls (33 +/- 2 s vs. 13 +/- 2 s). In addition, AQP4 -/- mice were found to have a higher seizure threshold (167 +/- 17 microA vs. 114 +/- 10 microA). To assess a potential effect of AQP4 on potassium kinetics, we used in vivo recording with po...
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Medical Subject Headings: sense organs
free text keywords: Cellular and Molecular Neuroscience, Neurology, Stimulation, Astrocyte, medicine.anatomical_structure, medicine, Homeostasis, Endocrinology, medicine.medical_specialty, Seizure threshold, Aquaporin 4, Neuroscience, Biology, Potassium, chemistry.chemical_element, chemistry, In vivo, Premovement neuronal activity, Internal medicine
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