publication . Other literature type . Article . 2018

Kisspeptin signaling in the brain.

Amy E. Oakley; Donald K. Clifton; Robert A. Steiner;
  • Published: 13 Nov 2018
Abstract
Kisspeptin (a product of the Kiss1 gene) and its receptor (GPR54 or Kiss1r) have emerged as key players in the regulation of reproduction. Mutations in humans or genetically targeted deletions in mice of either Kiss1 or Kiss1r cause profound hypogonadotropic hypogonadism. Neurons that express Kiss1/kisspeptin are found in discrete nuclei in the hypothalamus, as well as other brain regions in many vertebrates, and their distribution, regulation, and function varies widely across species. Kisspeptin neurons directly innervate and stimulate GnRH neurons, which are the final common pathway through which the brain regulates reproduction. Kisspeptin neurons are sexual...
Subjects
Medical Subject Headings: hormones, hormone substitutes, and hormone antagonists
free text keywords: Article, Endocrinology, Diabetes and Metabolism, Endocrinology, Gonadotropin secretion, Biology, Internal medicine, medicine.medical_specialty, medicine, Gonadotropin-releasing hormone, Neuroendocrinology, Kisspeptin, Neurokinin B, chemistry.chemical_compound, chemistry, Hypogonadotropic hypogonadism, medicine.disease, Androgen receptor, Hypothalamus
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publication . Other literature type . Article . 2018

Kisspeptin signaling in the brain.

Amy E. Oakley; Donald K. Clifton; Robert A. Steiner;