publication . Article . 2008

Effect of serotonin on small intestinal contractility in healthy volunteers

Wallin L; Bruusgaard H; Hans Gregersen; Arif F; Mb, Hansen;
Restricted English
  • Published: 01 Jan 2008
Abstract
Udgivelsesdato: 2008 The physiological significance of serotonin released into the intestinal lumen for the regulation of motility is unknown in humans. The aim of this study was to evaluate the effect of serotonin infused into the lumen of the gastric antrum, duodenum or the jejunum, on antro-duodeno-jejunal contractility in healthy human volunteers. Manometric recordings were obtained and the effects of either a standard meal, continuous intravenous infusion of serotonin (20 nmol/kg/min) or intraluminal bolus infusions of graded doses of serotonin (2.5, 25 or 250 nmol) were compared. In addition, platelet-depleted plasma levels of serotonin, blood pressure, he...
Subjects
free text keywords: Adult, Dose-Response Relationship, Drug, Duodenum, Female, Gastrointestinal Motility, Humans, Infusions, Intravenous, Instillation, Drug, Jejunum, Male, Middle Aged, Myoelectric Complex, Migrating, Pyloric Antrum, Reference Values, Serotonin
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publication . Article . 2008

Effect of serotonin on small intestinal contractility in healthy volunteers

Wallin L; Bruusgaard H; Hans Gregersen; Arif F; Mb, Hansen;