publication . Other literature type . Review . Article . 2010

Buruli ulcer: reductive evolution enhances pathogenicity of Mycobacterium ulcerans.

Timothy Stinear; Caroline Demangel;
Open Access
  • Published: 07 Sep 2010
  • Publisher: Springer Science and Business Media LLC
  • Country: Switzerland
Abstract
Buruli ulcer is an emerging human disease caused by infection with a slow-growing pathogen, Mycobacterium ulcerans, that produces mycolactone, a cytotoxin with immunomodulatory properties. The disease is associated with wetlands in certain tropical countries, and evidence for a role of insects in transmission of this pathogen is growing. Comparative genomic analysis has revealed that M. ulcerans arose from Mycobacterium marinum, a ubiquitous fast-growing aquatic species, by horizontal transfer of a virulence plasmid that carries a cluster of genes for mycolactone production, followed by reductive evolution. Here, the ecology, microbiology, evolutionary genomics ...
Subjects
Medical Subject Headings: bacterial infections and mycoses
free text keywords: General Immunology and Microbiology
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