publication . Article . Other literature type . 2011

Association between C reactive protein and coronary heart disease

Wensley, F; Gao, P; Burgess, S; Kaptoge, S; Di Angelantonio, E; Shah, T; Engert, JC; Clarke, R; Davey-Smith, G; Nordestgaard, BG; ...
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Open Access English
  • Published: 15 Feb 2011 Journal: BRITISH MEDICAL JOURNAL, volume 342, issue feb15 2 (issn: 0959-535X, eissn: 1468-5833, Copyright policy)
  • Country: United Kingdom
Abstract
OBJECTIVE: To use genetic variants as unconfounded proxies of C reactive protein concentration to study its causal role in coronary heart disease. DESIGN: Mendelian randomisation meta-analysis of individual participant data from 47 epidemiological studies in 15 countries. PARTICIPANTS: 194 418 participants, including 46 557 patients with prevalent or incident coronary heart disease. Information was available on four CRP gene tagging single nucleotide polymorphisms (rs3093077, rs1205, rs1130864, rs1800947), concentration of C reactive protein, and levels of other risk factors. MAIN OUTCOME MEASURES: Risk ratios for coronary heart disease associated with genetical...
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doi: 10.1136/bmj.d548
pmc: PMC3039696
pmid: 21325005
Subjects
free text keywords: General Medicine, Science & Technology, Life Sciences & Biomedicine, Medicine, General & Internal, General & Internal Medicine, CARDIOVASCULAR-DISEASE, INSTRUMENTAL VARIABLES, MYOCARDIAL-INFARCTION, RISK, METAANALYSIS, ATHEROSCLEROSIS, MARKERS, GENE, POLYMORPHISMS, INFLAMMATION, Coronary Disease, Female, Gene Frequency, Humans, Male, Mendelian Randomization Analysis, Middle Aged, Polymorphism, Single Nucleotide, Prospective Studies, Risk Factors, C Reactive Protein Coronary Heart Disease Genetics Collaboration (CCGC), 1117 Public Health And Health Services, no, Research, Molecular Genetics, Drugs: Cardiovascular System, Ischaemic Heart Disease, UMCG Approved, C-reactive protein, biology.protein, biology, Internal medicine, medicine.medical_specialty, medicine, business.industry, business, Coronary heart disease, Cardiology
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