publication . Other literature type . Article . 2015

Regulation of metabolism by the innate immune system

Denise E. Lackey; Jerrold M. Olefsky;
  • Published: 10 Nov 2015
  • Publisher: Springer Science and Business Media LLC
Abstract
Here, Denise Lackey and Jerrold Olefsky discuss the innate immune cells involved in secreting inflammatory factors during obesity. The role of innate immune cells in maintaining an anti-inflammatory and insulin-sensitive environment in the lean state is also reviewed. This Review also provides an overview of the mechanisms for regulating proinflammatory immune responses that could lead to future therapeutic opportunities to improve insulin sensitivity.
Subjects
Medical Subject Headings: bacteriabiochemical phenomena, metabolism, and nutrition
free text keywords: Endocrinology, Diabetes and Metabolism, Endocrinology, Adipose tissue macrophages, Inflammation, medicine.symptom, medicine, Innate immune system, Internal medicine, medicine.medical_specialty, Proinflammatory cytokine, Pyroptosis, CCL18, Biology, Immune system, Innate lymphoid cell, Immunology
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