publication . Other literature type . Article . 1981

Successful use of a physiologically acceptable artificial skin in the treatment of extensive burn injury.

Walter K. Jung; William C. Quinby; Ioannis V. Yannas; Conrado C. Bondoc; John F. Burke;
Open Access English
  • Published: 01 Oct 1981
Abstract
A bilayer artificial skin composed of a temporary Silastic epidermis and a porous collagen-chondroitn 6-sulfate fibrillar dermis, which is not removed, has been used to physiologically close up to 60% of the body surface following prompt excision of burn wounds in ten patients whose total burn size covered 50--95% body surface area (BSA). Following grafting, the dermal portion is populated with fibroblasts and vessels from the wound bed. The anatomic structure of the artificial dermis resembles normal dermis and serves as a template for the synthesis of new connective tissue and the formation of a "neodermis," while it is slowly biodegraded. This artificial skin...
Subjects
free text keywords: Research Article, Surgery, Connective tissue, medicine.anatomical_structure, medicine, Artificial skin, Body surface, Epidermis (botany), Anatomy, medicine.medical_specialty, Dermis, Silastic, Wound healing, business.industry, business, Burn injury
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