publication . Other literature type . Article . 2008

UNC93B1 delivers nucleotide-sensing toll-like receptors to endolysosomes

You-Me Kim;
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  • Published: 27 Feb 2008
  • Publisher: Springer Science and Business Media LLC
Abstract
The membrane protein UNC93B interacts with intracellular Toll-like receptors TLR7 and TLR9. This paper shows that UNC93B specifically controls TLR trafficking from the endoplasmic reticulum to the endolysosome but is not required for ligand recognition or signal initiation. Signalling by means of toll-like receptors (TLRs) is essential for the development of innate and adaptive immune responses1,2,3. UNC93B1, essential for signalling of TLR3, TLR7 and TLR9 in both humans and mice, physically interacts with these TLRs in the endoplasmic reticulum (ER)4,5,6. Here we show that the function of the polytopic membrane protein UNC93B1 is to deliver the nucleotide-sensi...
Subjects
free text keywords: Multidisciplinary
Abstract
The membrane protein UNC93B interacts with intracellular Toll-like receptors TLR7 and TLR9. This paper shows that UNC93B specifically controls TLR trafficking from the endoplasmic reticulum to the endolysosome but is not required for ligand recognition or signal initiation. Signalling by means of toll-like receptors (TLRs) is essential for the development of innate and adaptive immune responses1,2,3. UNC93B1, essential for signalling of TLR3, TLR7 and TLR9 in both humans and mice, physically interacts with these TLRs in the endoplasmic reticulum (ER)4,5,6. Here we show that the function of the polytopic membrane protein UNC93B1 is to deliver the nucleotide-sensi...
Subjects
free text keywords: Multidisciplinary
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