publication . Other literature type . Article . 2002

AtXPB1 functions in DNA repair and development

David Bouchez; Marie-Anne Van Sluys; Carlos FM Menck;
Open Access
  • Published: 23 Jan 2002
Abstract
Summary Nucleotide excision repair in Arabidopsis thaliana differs from other eukaryotes as it contains two paralogous copies of the corresponding XPB/RAD25 gene. In this work, the functional characterization of one copy, AtXPB1, is presented. The plant gene was able to partially complement the UV sensitivity of a yeast rad25 mutant strain, thus confirming its involvement in nucleotide excision repair. The biological role of AtXPB1 protein in A. thaliana was further ascertained by obtaining a homozygous mutant plant containing the AtXPB1 genomic sequence interrupted by a T-DNA insertion. The 3′ end of the mutant gene is disrupted, generating the expression of a ...
Subjects
Medical Subject Headings: fungifood and beverages
free text keywords: [SDV.GEN.GPL]Life Sciences [q-bio]/Genetics/Plants genetics
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