publication . Other literature type . Article . 2019

Utility of HbA1c assessment in people with diabetes awaiting liver transplantation.

Georgios Gkoutos; Subrata Ghosh; John Williams;
Open Access
  • Published: 30 Apr 2019
  • Publisher: Wiley
Abstract
AIMS To investigate the relationship between HbA1c and glucose in people with co-existing liver disease and diabetes awaiting transplant, and in those with diabetes but no liver disease. METHODS HbA1c and random plasma glucose data were collected for 125 people with diabetes without liver disease and for 29 people awaiting liver transplant with diabetes and cirrhosis. Cirrhosis was caused by non-alcoholic fatty liver disease, hepatitis C, alcoholic liver disease, hereditary haemochromatosis, polycystic liver/kidneys, cryptogenic/non-cirrhotic portal hypertension and α-1-antitrypsin-related disease. RESULTS The median (interquartile range) age of the diabetes wit...
Subjects
free text keywords: Internal Medicine, Endocrinology, Diabetes and Metabolism, Endocrinology
Related Organizations
Funded by
EC| OpenRiskNet
Project
OpenRiskNet
OpenRiskNet: Open e-Infrastructure to Support Data Sharing, Knowledge Integration and in silico Analysis and Modelling in Risk Assessment
  • Funder: European Commission (EC)
  • Project Code: 731075
  • Funding stream: H2020 | RIA
,
NIH| Mouse Phenotyping Informatics Infrastructure - MP12
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 5UM1HG006370-08
  • Funding stream: NATIONAL HUMAN GENOME RESEARCH INSTITUTE
,
NSF| cROP: Common Reference Ontologies and Applications for Plant Biology
Project
  • Funder: National Science Foundation (NSF)
  • Project Code: 1340112
  • Funding stream: Directorate for Biological Sciences | Division of Integrative Organismal Systems
26 references, page 1 of 2

1 Tolman KG, Fonseca V, Dalpiaz A, Tan MH. Spectrum of liver disease in type 2 diabetes and management of patients with diabetes and liver disease. Diabetes Care 2007; 30: 734–743.17327353 [PubMed]

2 Ahmadieh H, Azar ST. Liver disease and diabetes: association, pathophysiology, and management. Diabetes Res Clin Pract 2014; 104: 53–62.24485856 [OpenAIRE] [PubMed]

3 Lecube A, Hernandez C, Genesca J, Simo R. Proinflammatory cytokines, insulin resistance, and insulin secretion in chronic hepatitis C patients: A case‐control study. Diabetes Care 2006; 29: 1096–1101.16644643 [PubMed]

4 Garcia‐Compean D, Jaquez‐Quintana JO, Gonzalez‐Gonzalez JA, Maldonado‐Garza H. Liver cirrhosis and diabetes: risk factors, pathophysiology, clinical implications and management. World J Gastroenterol 2009; 15: 280–288.19140227 [OpenAIRE] [PubMed]

5 Shivaswamy V, Boerner B, Larsen J. Post‐Transplant Diabetes Mellitus: Causes, Treatment, and Impact on Outcomes. Endocr Rev 2016; 37: 37–61.26650437 [OpenAIRE] [PubMed]

6 Webber J, Chua S, Cockwell P, Haydon G, Jobanputra P, Lester W et al Effects of concurrent illnesses and treatments on surrogate glycaemic markers. Diabet Med 2017; 34 (Suppl. 1): P138 (Abstract).

7 Report of a World Health Organization Consultation . Use of glycated haemoglobin (HbA 1c) in the diagnosis of diabetes mellitus. Diabetes Res Clin Pract 2011;93:299–309.

8 Dowd RP, Manning PW, Ahmed N, Mason CL, Round RA, Nightingale PG et al Post introduction of HbA1c as a diagnostic test: consequences for requesting and reporting. Diabet Med 2015; 32 (Suppl. 1): P440.

9 American Diabetes Association . Position statement. Diagnosis and classification of diabetes mellitus. Diabetes Care 2014; 37 (Suppl. 1): S81–S90.24357215 [PubMed]

10 Manley SE, O'Brien KT, Quinlan D, Round RA, Nightingale PG, Ali F et al Can HbA 1c detect undiagnosed diabetes in acute medical hospital admissions?Diabetes Res Clin Pract 2016; 115: 106–114.27012459 [PubMed]

11 Dowd RP, Round RA, Mason CL, Nightingale PG, Ghosh SG, Hanif W et al Review of HbA 1c results >120 mmol/mol as patients may require urgent assessment if request for diagnosis of Type 2 diabetes. Diabet Med 2014; 31 (Suppl 1): P466.

12 Kadri F, Stuart K, Cramb R, Manley S, Mtemererwa B, Ghosh S. HbA 1c interpretation and its caveats: a case of targeting apparently good glycaemic control causing severe hypoglycaemia. International Diabetes Federation (IDF) meeting, Vancouver, Canada, 30 November to 4 December, 2015. Abstract: 0550‐P.

13 Nadelson J, Satapathy SK, Nair S. Glycated hemoglobin levels in patients with decompensated cirrhosis. Int J Endocrinol 2016; 2016: Article ID 8390210. 10.1155/2016/8390210. [OpenAIRE] [DOI]

14 Malinchoc M, Kamath PS, Gordon FD, Peine CJ, Rank J, ter Borg PC. A model to predict poor survival in patients undergoing transjugular intrahepatic portosystemic shunts. Hepatology 2000; 31: 864–871.10733541 [PubMed]

15 Manley SE, Hikin LJ, Round RA, Manning PW, Luzio SD, Dunseath GJ et al Comparison of IFCC‐calibrated HbA 1c from laboratory and point of care testing systems. Diabetes Res Clin Pract 2014; 105: 364–372.24985893 [PubMed]

26 references, page 1 of 2
Abstract
AIMS To investigate the relationship between HbA1c and glucose in people with co-existing liver disease and diabetes awaiting transplant, and in those with diabetes but no liver disease. METHODS HbA1c and random plasma glucose data were collected for 125 people with diabetes without liver disease and for 29 people awaiting liver transplant with diabetes and cirrhosis. Cirrhosis was caused by non-alcoholic fatty liver disease, hepatitis C, alcoholic liver disease, hereditary haemochromatosis, polycystic liver/kidneys, cryptogenic/non-cirrhotic portal hypertension and α-1-antitrypsin-related disease. RESULTS The median (interquartile range) age of the diabetes wit...
Subjects
free text keywords: Internal Medicine, Endocrinology, Diabetes and Metabolism, Endocrinology
Related Organizations
Funded by
EC| OpenRiskNet
Project
OpenRiskNet
OpenRiskNet: Open e-Infrastructure to Support Data Sharing, Knowledge Integration and in silico Analysis and Modelling in Risk Assessment
  • Funder: European Commission (EC)
  • Project Code: 731075
  • Funding stream: H2020 | RIA
,
NIH| Mouse Phenotyping Informatics Infrastructure - MP12
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 5UM1HG006370-08
  • Funding stream: NATIONAL HUMAN GENOME RESEARCH INSTITUTE
,
NSF| cROP: Common Reference Ontologies and Applications for Plant Biology
Project
  • Funder: National Science Foundation (NSF)
  • Project Code: 1340112
  • Funding stream: Directorate for Biological Sciences | Division of Integrative Organismal Systems
26 references, page 1 of 2

1 Tolman KG, Fonseca V, Dalpiaz A, Tan MH. Spectrum of liver disease in type 2 diabetes and management of patients with diabetes and liver disease. Diabetes Care 2007; 30: 734–743.17327353 [PubMed]

2 Ahmadieh H, Azar ST. Liver disease and diabetes: association, pathophysiology, and management. Diabetes Res Clin Pract 2014; 104: 53–62.24485856 [OpenAIRE] [PubMed]

3 Lecube A, Hernandez C, Genesca J, Simo R. Proinflammatory cytokines, insulin resistance, and insulin secretion in chronic hepatitis C patients: A case‐control study. Diabetes Care 2006; 29: 1096–1101.16644643 [PubMed]

4 Garcia‐Compean D, Jaquez‐Quintana JO, Gonzalez‐Gonzalez JA, Maldonado‐Garza H. Liver cirrhosis and diabetes: risk factors, pathophysiology, clinical implications and management. World J Gastroenterol 2009; 15: 280–288.19140227 [OpenAIRE] [PubMed]

5 Shivaswamy V, Boerner B, Larsen J. Post‐Transplant Diabetes Mellitus: Causes, Treatment, and Impact on Outcomes. Endocr Rev 2016; 37: 37–61.26650437 [OpenAIRE] [PubMed]

6 Webber J, Chua S, Cockwell P, Haydon G, Jobanputra P, Lester W et al Effects of concurrent illnesses and treatments on surrogate glycaemic markers. Diabet Med 2017; 34 (Suppl. 1): P138 (Abstract).

7 Report of a World Health Organization Consultation . Use of glycated haemoglobin (HbA 1c) in the diagnosis of diabetes mellitus. Diabetes Res Clin Pract 2011;93:299–309.

8 Dowd RP, Manning PW, Ahmed N, Mason CL, Round RA, Nightingale PG et al Post introduction of HbA1c as a diagnostic test: consequences for requesting and reporting. Diabet Med 2015; 32 (Suppl. 1): P440.

9 American Diabetes Association . Position statement. Diagnosis and classification of diabetes mellitus. Diabetes Care 2014; 37 (Suppl. 1): S81–S90.24357215 [PubMed]

10 Manley SE, O'Brien KT, Quinlan D, Round RA, Nightingale PG, Ali F et al Can HbA 1c detect undiagnosed diabetes in acute medical hospital admissions?Diabetes Res Clin Pract 2016; 115: 106–114.27012459 [PubMed]

11 Dowd RP, Round RA, Mason CL, Nightingale PG, Ghosh SG, Hanif W et al Review of HbA 1c results >120 mmol/mol as patients may require urgent assessment if request for diagnosis of Type 2 diabetes. Diabet Med 2014; 31 (Suppl 1): P466.

12 Kadri F, Stuart K, Cramb R, Manley S, Mtemererwa B, Ghosh S. HbA 1c interpretation and its caveats: a case of targeting apparently good glycaemic control causing severe hypoglycaemia. International Diabetes Federation (IDF) meeting, Vancouver, Canada, 30 November to 4 December, 2015. Abstract: 0550‐P.

13 Nadelson J, Satapathy SK, Nair S. Glycated hemoglobin levels in patients with decompensated cirrhosis. Int J Endocrinol 2016; 2016: Article ID 8390210. 10.1155/2016/8390210. [OpenAIRE] [DOI]

14 Malinchoc M, Kamath PS, Gordon FD, Peine CJ, Rank J, ter Borg PC. A model to predict poor survival in patients undergoing transjugular intrahepatic portosystemic shunts. Hepatology 2000; 31: 864–871.10733541 [PubMed]

15 Manley SE, Hikin LJ, Round RA, Manning PW, Luzio SD, Dunseath GJ et al Comparison of IFCC‐calibrated HbA 1c from laboratory and point of care testing systems. Diabetes Res Clin Pract 2014; 105: 364–372.24985893 [PubMed]

26 references, page 1 of 2
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