publication . Other literature type . Article . 2009

TREM and TREM-like receptors in inflammation and disease ☆ ☆☆

Jill W Ford; Daniel W McVicar;
Open Access English
  • Published: 01 Feb 2009
Abstract
Since the discovery of triggering receptor expressed on myeloid cells (TREM)-1 in 2000, evidence documenting the profound ability of the TREM and TREM-like receptors to regulate inflammation has rapidly accumulated. Monocytes, macrophages, myeloid dendritic cells, plasmacytoid dendritic cells, neutrophils, microglia, osteoclasts, and platelets all express at least one member of the TREM family, underscoring the importance of these proteins in the regulation of innate resistance. Recent work on the TREM family includes: characterization of a new receptor expressed on plasmacytoid dendritic cells; definition of a key role for TREM in inflammatory bowel disease and...
Subjects
free text keywords: Article, Immunology, Immunology and Allergy, Cell adhesion, Signal transduction, Receptor, Cell biology, Microglia, medicine.anatomical_structure, medicine, Myeloid, Integrin, biology.protein, biology, Regulation of gene expression, Inflammation, medicine.symptom
Abstract
Since the discovery of triggering receptor expressed on myeloid cells (TREM)-1 in 2000, evidence documenting the profound ability of the TREM and TREM-like receptors to regulate inflammation has rapidly accumulated. Monocytes, macrophages, myeloid dendritic cells, plasmacytoid dendritic cells, neutrophils, microglia, osteoclasts, and platelets all express at least one member of the TREM family, underscoring the importance of these proteins in the regulation of innate resistance. Recent work on the TREM family includes: characterization of a new receptor expressed on plasmacytoid dendritic cells; definition of a key role for TREM in inflammatory bowel disease and...
Subjects
free text keywords: Article, Immunology, Immunology and Allergy, Cell adhesion, Signal transduction, Receptor, Cell biology, Microglia, medicine.anatomical_structure, medicine, Myeloid, Integrin, biology.protein, biology, Regulation of gene expression, Inflammation, medicine.symptom
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