publication . Article . Other literature type . 2007

The Fusarium verticillioides FUM Gene Cluster Encodes a Zn(II)2Cys6 Protein That Affects FUM Gene Expression and Fumonisin Production

Brown, Daren W.; Butchko, Robert A. E.; Busman, Mark; Proctor, Robert H.;
Open Access
  • Published: 04 May 2007 Journal: Eukaryotic Cell, volume 6, pages 1,210-1,218 (issn: 1535-9778, eissn: 1535-9786, Copyright policy)
  • Publisher: American Society for Microbiology
Abstract
<jats:title>ABSTRACT</jats:title> <jats:p>Fumonisins are mycotoxins produced by some <jats:italic>Fusarium</jats:italic> species and can contaminate maize or maize products. Ingestion of fumonisins is associated with diseases, including cancer and neural tube defects, in humans and animals. In fungi, genes involved in the synthesis of mycotoxins and other secondary metabolites are often located adjacent to each other in gene clusters. Such genes can encode structural enzymes, regulatory proteins, and/or proteins that provide self-protection. The fumonisin biosynthetic gene cluster includes 16 genes, none of which appear to play a role in regulation. In this stud...
Subjects
Medical Subject Headings: food and beverages
free text keywords: Molecular Biology, Microbiology, General Medicine, Fumonisin, chemistry.chemical_compound, chemistry, Gene, Biology, Genetics, Polyketide synthase, biology.protein, Mutant, Gene cluster, Gene expression, Transcriptional regulation, Complementation, Articles
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