publication . Other literature type . Article . 1996

Preclinical Evidence of Alzheimer's Disease in Persons Homozygous for the ε4 Allele for Apolipoprotein E

Eric M. Reiman; Richard J. Caselli; Lang S. Yun; Kewei Chen; Daniel Bandy; Satoshi Minoshima; Stephen N. Thibodeau; David Osborne;
  • Published: 21 Mar 1996
  • Publisher: Massachusetts Medical Society
Abstract
Background Variants of the apolipoprotein E allele appear to account for most cases of late-onset Alzheimer's disease, and persons with two copies of the e4 allele appear to have an especially high risk of dementia. Positron-emission tomography (PET) has identified specific regions of the brain in which the rate of glucose metabolism declines progressively in patients with probable Alzheimer's disease. We used PET to investigate whether these same regions of the brain are affected in subjects homozygous for the e4 allele before the onset of cognitive impairment. Methods Apolipoprotein E genotypes were established in 235 volunteers 50 to 65 years of age who repor...
Subjects
free text keywords: Oncology, medicine.medical_specialty, medicine, Dementia, medicine.disease, Surgery, Alzheimer's disease, Apolipoprotein E, Case-control study, Risk factor, Pathology, Family history, Allele, business.industry, business, Degenerative disease, Internal medicine
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publication . Other literature type . Article . 1996

Preclinical Evidence of Alzheimer's Disease in Persons Homozygous for the ε4 Allele for Apolipoprotein E

Eric M. Reiman; Richard J. Caselli; Lang S. Yun; Kewei Chen; Daniel Bandy; Satoshi Minoshima; Stephen N. Thibodeau; David Osborne;