publication . Article . Other literature type . 2004

Imaging Brain Amyloid in Alzheimer's Disease With Pittsburgh Compound-B

Imaging Amyloid in AD with PIB
William E. Klunk; Henry Engler; Agneta Nordberg; Yanming Wang; Gunnar Blomqvist; Daniel P. Holt; Mats Bergström; Irina Savitcheva; Guo-Feng Huang; Sergio Estrada; ...
Restricted
  • Published: 21 Jan 2004 Journal: Yearbook of Pathology and Laboratory Medicine, volume 2,006, pages 190-191 (issn: 1077-9108, Copyright policy)
  • Publisher: Elsevier BV
Abstract
This report describes the first human study of a novel amyloid-imaging positron emission tomography (PET) tracer, termed Pittsburgh Compound-B (PIB), in 16 patients with diagnosed mild AD and 9 controls. Compared with controls, AD patients typically showed marked retention of PIB in areas of association cortex known to contain large amounts of amyloid deposits in AD. In the AD patient group, PIB retention was increased most prominently in frontal cortex (1.94-fold, p 0.0001). Large increases also were observed in parietal (1.71-fold, p 0.0002), temporal (1.52-fold, p 0.002), and occipital (1.54-fold, p 0.002) cortex and the striatum (1.76-fold, p 0.0001). PIB re...
Subjects
free text keywords: Imaging brain, Pathology, medicine.medical_specialty, medicine, business.industry, business, Amyloid, Pittsburgh compound B, chemistry.chemical_compound, chemistry, Disease, Cortex (botany), Alzheimer's disease biomarkers, Florbetaben, Posterior parietal cortex, White matter, medicine.anatomical_structure, Alzheimer's disease, medicine.disease, Central nervous system disease
Related Organizations
Powered by OpenAIRE Open Research Graph
Any information missing or wrong?Report an Issue
publication . Article . Other literature type . 2004

Imaging Brain Amyloid in Alzheimer's Disease With Pittsburgh Compound-B

Imaging Amyloid in AD with PIB
William E. Klunk; Henry Engler; Agneta Nordberg; Yanming Wang; Gunnar Blomqvist; Daniel P. Holt; Mats Bergström; Irina Savitcheva; Guo-Feng Huang; Sergio Estrada; ...