publication . Article . Other literature type . 2007

Efficient Association Mapping of Quantitative Trait Loci with Selective Genotyping

Bevan Emma Huang; Lin, Dy;
Open Access English
  • Published: 30 Jan 2007 Journal: The American Journal of Human Genetics, issue 3, pages 567-576 (issn: 00029297, Copyright policy)
  • Publisher: The American Society of Human Genetics. Published by Elsevier Inc.
Abstract
Selective genotyping (i.e., genotyping only those individuals with extreme phenotypes) can greatly improve the power to detect and map quantitative trait loci in genetic association studies. Because selection depends on the phenotype, the resulting data cannot be properly analyzed by standard statistical methods. We provide appropriate likelihoods for assessing the effects of genotypes and haplotypes on quantitative traits under selective-genotyping designs. We demonstrate that the likelihood-based methods are highly effective in identifying causal variants and are substantially more powerful than existing methods.
Subjects
free text keywords: Report, Genetics(clinical), Genetics, Genotyping, Association mapping, Haplotype, Genetic association, Gene mapping, Quantitative trait locus, Phenotype, Genotype, Biology
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