publication . Other literature type . Article . 2006

Improved Power Offered by a Score Test for Linkage Disequilibrium Mapping of Quantitative-Trait Loci by Selective Genotyping

Chris Wallace; Juliet M. Chapman; David G. Clayton;
Open Access English
  • Published: 05 Jan 2006
  • Publisher: The American Society of Human Genetics
Abstract
Selective genotyping is used to increase efficiency in genetic association studies of quantitative traits by genotyping only those individuals who deviate from the population mean. However, selection distorts the conditional distribution of the trait given genotype, and such data sets are usually analyzed using case-control methods, quantitative analysis within selected groups, or a combination of both. We show that Hotelling's T 2 test, recently proposed for association studies of one or several tagging single-nucleotide polymorphisms in a prospective (i.e., trait given genotype) design, can also be applied to the retrospective (i.e., genotype given trait) sele...
Subjects
free text keywords: Report, Genetics(clinical), Genetics, Genetic association, Quantitative trait locus, Linkage Disequilibrium Mapping, Linkage disequilibrium, Genotyping, Score test, Trait, Biology, Genotype
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