publication . Other literature type . Article . 2018

Phosphorylation of Threonine 175 Tau in the Induction of Tau Pathology in Amyotrophic Lateral Sclerosis-Frontotemporal Spectrum Disorder (ALS-FTSD). A Review.

Alexander J. Moszczynski; Matthew A. Hintermayer; Michael J. Strong; Michael J. Strong;
  • Published: 20 Apr 2018
  • Publisher: Frontiers Media SA
Abstract
Approximately 50 to 60% of all patients with amyotrophic lateral sclerosis (ALS) will develop a deficit of frontotemporal function, ranging from frontotemporal dementia (FTD) to one or more deficits of neuropsychological, speech or language function which are collectively known as the frontotemporal spectrum disorders of ALS (ALS-FTSD). While the neuropathology underlying these disorders is most consistent with a widespread alteration in the metabolism of transactive response DNA-binding protein 43 (TDP-43), in both ALS with cognitive impairment (ALSci) and ALS with FTD (ALS-FTD; also known as MND-FTD) there is evidence for alterations in the metabolism of the m...
Subjects
Medical Subject Headings: mental disorders
free text keywords: amyotrophic lateral sclerosis, chronic traumatic encephalopathy, frontotemporal dementia, TDP-43, microtubule associated tau protein, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571, Review, Tauopathy, medicine.disease, medicine, Phosphorylation, Traumatic brain injury, Neuroscience, Neuropathology, Tau protein, biology.protein, biology, Psychology
128 references, page 1 of 9

Abrahams S.Goldstein L. H.Simmons A.Brammer M.Williams S. C.Giampietro V.. (2004). Word retrieva l in amyotrophic lateral sclerosis: a functional magnetic resonance imaging study. Brain 127, 1507–1517. 10.1093/brain/awh170 15163610 [OpenAIRE] [PubMed] [DOI]

Adenzato M.Cavallo M.Enrici I. (2010). Theory of mind ability in the behavioural variant of frontotemporal dementia: an analysis of the neural, cognitive, and social levels. Neuropsychologia 48, 2–12. 10.1016/j.neuropsychologia.2009.08.001 19666039 [OpenAIRE] [PubMed] [DOI]

Agosta F.Canu E.Valsasina P.Riva N.Prelle A.Comi G.. (2013). Divergent brain network connectivity in amyotrophic lateral sclerosis. Neurobiol. Aging 34, 419–427. 10.1016/j.neurobiolaging.2012.04.015 22608240 [OpenAIRE] [PubMed] [DOI]

Agosta F.Ferraro P. M.Riva N.Spinelli E. G.ChiòA.Canu E.. (2016). Structural brain correlates of cognitive and behavioral impairment in MND. Hum. Brain Mapp.37, 1614–1626. 10.1002/hbm.23124 26833930 [OpenAIRE] [PubMed] [DOI]

Agosta F.Valsasina P.Absinta M.Riva N.Sala S.Prelle A.. (2011). Sensorimotor functional connectivity changes in amyotrophic lateral sclerosis. Cereb. Cortex 21, 2291–2298. 10.1093/cercor/bhr002 21368084 [OpenAIRE] [PubMed] [DOI]

Albayram O.Kondo A.Mannix R.Smith C.Tsai C. Y.Li C.. (2017). Cis P-tau is induced in clinical and preclinical brain injury and contributes to post-injury sequelae. Nat. Commun.8:1000. 10.1038/s41467-017-01068-4 29042562 [OpenAIRE] [PubMed] [DOI]

Amador-Ortiz C.Lin W. L.Ahmed Z.Personett D.Davies P.Duara R.. (2007). TDP-43 immunoreactivity in hippocampal sclerosis and Alzheimer's disease. Ann. Neurol.61, 435–445. 10.1002/ana.21154 17469117 [OpenAIRE] [PubMed] [DOI]

Ambikairajah A.Devenney E.Flanagan E.Yew B.Mioshi E.Kiernan M. C.. (2014). A visual MRI atrophy rating scale for the amyotrophic lateral sclerosis-frontotemporal dementia continuum. Amyotroph. Lateral Scler. Frontotemporal Degener.15, 226–234. 10.3109/21678421.2014.880180 24533506 [OpenAIRE] [PubMed] [DOI]

Arai T.Hasegawa M.Akiyama H.Ikeda K.Nonaka T.Mori H.. (2006). TDP-43 is a component of ubiquitin-positive tau-negative inclusions in frontotemporal lobar degeneration and amyotrophic lateral sclerosis. Biochem. Biophys. Res. Commun.351, 602–611. 10.1016/j.bbrc.2006.10.093 17084815 [OpenAIRE] [PubMed] [DOI]

Ash P. E.Bieniek K. F.Gendron T. F.Caulfield T.Lin W. L.Dejesus-Hernandez M.. (2013). Unconventional translation of C9ORF72 GGGGCC expansion generates insoluble polypeptides specific to c9FTD/ALS. Neuron 77, 639–646. 10.1016/j.neuron.2013.02.004 23415312 [OpenAIRE] [PubMed] [DOI]

Atzori C.Ghetti B.Piva R.Srinivasan A. N.Zolo P.Delisle M. B. (2001). Activation of the JNK/p38 pathway occurs in diseases charcterized by tau protein pathology and is related to tau phosphorylation but not to apoptosis. J. Neuropathol. Exp. Neurol. 60, 1190–1197. 10.1093/jnen/60.12.1190 11764091 [OpenAIRE] [PubMed] [DOI]

Bak T. H.Hodges J. R. (2001). Motor neurone disease, dementia and aphasia; coincidence, co-occurrence or continuum? J. Neurol. 248, 260–270. 10.1007/s004150170199 11374089 [OpenAIRE] [PubMed] [DOI]

Bede P.Bokde A. L.Byrne S.Elamin M.McLaughlin R. L.Kenna K.. (2013). Multiparametric MRI study of ALS stratified for the C9orf72 genotype. Neurology 81, 361–369. 10.1212/WNL.0b013e31829c5eee 23771489 [OpenAIRE] [PubMed] [DOI]

Behrouzi R.Liu X.Wu D.Robinson A. C.Tanaguchi-Watanabe S.Rollinson S.. (2016). Pathological tau deposition in motor neurone disease and frontotemporal lobar degeneration associated with TDP-43 proteinopathy. Acta Neuropathol. Commun.4:33. 10.1186/s40478-016-0301-z 27036121 [OpenAIRE] [PubMed] [DOI]

Cerami C.Dodich A.Canessa N.Crespi C.Iannaccone S.Corbo M.. (2014). Emotional empathy in amyotrophic lateral sclerosis: a behavioural and voxel-based morphometry study. Amyotroph. Lateral Scler. Frontotemporal Degener.15, 21–29. 10.3109/21678421.2013.785568 23586919 [OpenAIRE] [PubMed] [DOI]

128 references, page 1 of 9
Abstract
Approximately 50 to 60% of all patients with amyotrophic lateral sclerosis (ALS) will develop a deficit of frontotemporal function, ranging from frontotemporal dementia (FTD) to one or more deficits of neuropsychological, speech or language function which are collectively known as the frontotemporal spectrum disorders of ALS (ALS-FTSD). While the neuropathology underlying these disorders is most consistent with a widespread alteration in the metabolism of transactive response DNA-binding protein 43 (TDP-43), in both ALS with cognitive impairment (ALSci) and ALS with FTD (ALS-FTD; also known as MND-FTD) there is evidence for alterations in the metabolism of the m...
Subjects
Medical Subject Headings: mental disorders
free text keywords: amyotrophic lateral sclerosis, chronic traumatic encephalopathy, frontotemporal dementia, TDP-43, microtubule associated tau protein, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571, Review, Tauopathy, medicine.disease, medicine, Phosphorylation, Traumatic brain injury, Neuroscience, Neuropathology, Tau protein, biology.protein, biology, Psychology
128 references, page 1 of 9

Abrahams S.Goldstein L. H.Simmons A.Brammer M.Williams S. C.Giampietro V.. (2004). Word retrieva l in amyotrophic lateral sclerosis: a functional magnetic resonance imaging study. Brain 127, 1507–1517. 10.1093/brain/awh170 15163610 [OpenAIRE] [PubMed] [DOI]

Adenzato M.Cavallo M.Enrici I. (2010). Theory of mind ability in the behavioural variant of frontotemporal dementia: an analysis of the neural, cognitive, and social levels. Neuropsychologia 48, 2–12. 10.1016/j.neuropsychologia.2009.08.001 19666039 [OpenAIRE] [PubMed] [DOI]

Agosta F.Canu E.Valsasina P.Riva N.Prelle A.Comi G.. (2013). Divergent brain network connectivity in amyotrophic lateral sclerosis. Neurobiol. Aging 34, 419–427. 10.1016/j.neurobiolaging.2012.04.015 22608240 [OpenAIRE] [PubMed] [DOI]

Agosta F.Ferraro P. M.Riva N.Spinelli E. G.ChiòA.Canu E.. (2016). Structural brain correlates of cognitive and behavioral impairment in MND. Hum. Brain Mapp.37, 1614–1626. 10.1002/hbm.23124 26833930 [OpenAIRE] [PubMed] [DOI]

Agosta F.Valsasina P.Absinta M.Riva N.Sala S.Prelle A.. (2011). Sensorimotor functional connectivity changes in amyotrophic lateral sclerosis. Cereb. Cortex 21, 2291–2298. 10.1093/cercor/bhr002 21368084 [OpenAIRE] [PubMed] [DOI]

Albayram O.Kondo A.Mannix R.Smith C.Tsai C. Y.Li C.. (2017). Cis P-tau is induced in clinical and preclinical brain injury and contributes to post-injury sequelae. Nat. Commun.8:1000. 10.1038/s41467-017-01068-4 29042562 [OpenAIRE] [PubMed] [DOI]

Amador-Ortiz C.Lin W. L.Ahmed Z.Personett D.Davies P.Duara R.. (2007). TDP-43 immunoreactivity in hippocampal sclerosis and Alzheimer's disease. Ann. Neurol.61, 435–445. 10.1002/ana.21154 17469117 [OpenAIRE] [PubMed] [DOI]

Ambikairajah A.Devenney E.Flanagan E.Yew B.Mioshi E.Kiernan M. C.. (2014). A visual MRI atrophy rating scale for the amyotrophic lateral sclerosis-frontotemporal dementia continuum. Amyotroph. Lateral Scler. Frontotemporal Degener.15, 226–234. 10.3109/21678421.2014.880180 24533506 [OpenAIRE] [PubMed] [DOI]

Arai T.Hasegawa M.Akiyama H.Ikeda K.Nonaka T.Mori H.. (2006). TDP-43 is a component of ubiquitin-positive tau-negative inclusions in frontotemporal lobar degeneration and amyotrophic lateral sclerosis. Biochem. Biophys. Res. Commun.351, 602–611. 10.1016/j.bbrc.2006.10.093 17084815 [OpenAIRE] [PubMed] [DOI]

Ash P. E.Bieniek K. F.Gendron T. F.Caulfield T.Lin W. L.Dejesus-Hernandez M.. (2013). Unconventional translation of C9ORF72 GGGGCC expansion generates insoluble polypeptides specific to c9FTD/ALS. Neuron 77, 639–646. 10.1016/j.neuron.2013.02.004 23415312 [OpenAIRE] [PubMed] [DOI]

Atzori C.Ghetti B.Piva R.Srinivasan A. N.Zolo P.Delisle M. B. (2001). Activation of the JNK/p38 pathway occurs in diseases charcterized by tau protein pathology and is related to tau phosphorylation but not to apoptosis. J. Neuropathol. Exp. Neurol. 60, 1190–1197. 10.1093/jnen/60.12.1190 11764091 [OpenAIRE] [PubMed] [DOI]

Bak T. H.Hodges J. R. (2001). Motor neurone disease, dementia and aphasia; coincidence, co-occurrence or continuum? J. Neurol. 248, 260–270. 10.1007/s004150170199 11374089 [OpenAIRE] [PubMed] [DOI]

Bede P.Bokde A. L.Byrne S.Elamin M.McLaughlin R. L.Kenna K.. (2013). Multiparametric MRI study of ALS stratified for the C9orf72 genotype. Neurology 81, 361–369. 10.1212/WNL.0b013e31829c5eee 23771489 [OpenAIRE] [PubMed] [DOI]

Behrouzi R.Liu X.Wu D.Robinson A. C.Tanaguchi-Watanabe S.Rollinson S.. (2016). Pathological tau deposition in motor neurone disease and frontotemporal lobar degeneration associated with TDP-43 proteinopathy. Acta Neuropathol. Commun.4:33. 10.1186/s40478-016-0301-z 27036121 [OpenAIRE] [PubMed] [DOI]

Cerami C.Dodich A.Canessa N.Crespi C.Iannaccone S.Corbo M.. (2014). Emotional empathy in amyotrophic lateral sclerosis: a behavioural and voxel-based morphometry study. Amyotroph. Lateral Scler. Frontotemporal Degener.15, 21–29. 10.3109/21678421.2013.785568 23586919 [OpenAIRE] [PubMed] [DOI]

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publication . Other literature type . Article . 2018

Phosphorylation of Threonine 175 Tau in the Induction of Tau Pathology in Amyotrophic Lateral Sclerosis-Frontotemporal Spectrum Disorder (ALS-FTSD). A Review.

Alexander J. Moszczynski; Matthew A. Hintermayer; Michael J. Strong; Michael J. Strong;