publication . Article . Other literature type . 2007

A second generation human haplotype map of over 3.1 million SNPs

Daniel Richter;
English
  • Published: 18 Oct 2007 Journal: Nature, volume 449, issue 7,164 (issn: 0028-0836, eissn: 1476-4679, Copyright policy)
Abstract
We describe the Phase II HapMap, which characterizes over 3.1 million human single nucleotide polymorphisms (SNPs) genotyped in 270 individuals from four geographically diverse populations and includes 25-35% of common SNP variation in the populations surveyed. The map is estimated to capture untyped common variation with an average maximum r 2 of between 0.9 and 0.96 depending on population. We demonstrate that the current generation of commercial genome-wide genotyping products captures common Phase II SNPs with an average maximum r 2 of up to 0.8 in African and up to 0.95 in non-African populations, and that potential gains in power in association studies can...
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Other literature type . 2007
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Other literature type . 2007
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http://dx.doi.org/10.1038/natu...
Other literature type . 2007
Provider: Datacite
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