publication . Article . Other literature type . 2009

Impaired astrocytic gap junction coupling and potassium buffering in a mouse model of tuberous sclerosis complex

Lin Xu; Ling-Hui Zeng; Michael Wong;
Open Access English
  • Published: 01 May 2009 Journal: Neurobiology of Disease, volume 34, issue 2, pages 291-299
  • Publisher: Elsevier
Abstract
Abnormalities in astrocytes occur in the brains of patients with Tuberous Sclerosis Complex (TSC) and may contribute to the pathogenesis of neurological dysfunction in this disease. Here, we report that knock-out mice with Tsc1 gene inactivation in glia (Tsc1GFAPCKO mice) exhibit decreased expression of the astrocytic connexin protein, Cx43, and an associated impairment in gap junction coupling between astrocytes. Correspondingly, hippocampal slices from Tsc1GFAPCKO mice have increased extracellular potassium concentration in response to stimulation. This impaired potassium buffering can be attributed to abnormal gap junction coupling, as a gap junction inhibito...
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Subjects
free text keywords: Tuberous sclerosis, Epilepsy, Seizures, Astrocyte, Glia, Connexin, Article, Neurology, lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry, lcsh:RC321-571, Biology, Stimulation, Cell biology, Neuroscience, medicine.anatomical_structure, medicine, Gap junction, Potassium, chemistry.chemical_element, chemistry, Patch clamp, TSC1, Hippocampal formation
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DOAJ-Articles
Article . 2009
Europe PubMed Central
Other literature type . 2009
http://dx.doi.org/10.1016/j.nb...
Other literature type . 2009
Provider: Datacite
Abstract
Abnormalities in astrocytes occur in the brains of patients with Tuberous Sclerosis Complex (TSC) and may contribute to the pathogenesis of neurological dysfunction in this disease. Here, we report that knock-out mice with Tsc1 gene inactivation in glia (Tsc1GFAPCKO mice) exhibit decreased expression of the astrocytic connexin protein, Cx43, and an associated impairment in gap junction coupling between astrocytes. Correspondingly, hippocampal slices from Tsc1GFAPCKO mice have increased extracellular potassium concentration in response to stimulation. This impaired potassium buffering can be attributed to abnormal gap junction coupling, as a gap junction inhibito...
Persistent Identifiers
Subjects
free text keywords: Tuberous sclerosis, Epilepsy, Seizures, Astrocyte, Glia, Connexin, Article, Neurology, lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry, lcsh:RC321-571, Biology, Stimulation, Cell biology, Neuroscience, medicine.anatomical_structure, medicine, Gap junction, Potassium, chemistry.chemical_element, chemistry, Patch clamp, TSC1, Hippocampal formation
Related Organizations
Download fromView all 5 versions
DOAJ-Articles
Article . 2009
Europe PubMed Central
Other literature type . 2009
http://dx.doi.org/10.1016/j.nb...
Other literature type . 2009
Provider: Datacite
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