publication . Other literature type . Article . 2013

Identity by Descent: Variation in Meiosis, Across Genomes, and in Populations

Elizabeth A. Thompson;
Open Access English
  • Published: 03 Jun 2013
  • Publisher: Genetics Society of America
Abstract
Gene identity by descent (IBD) is a fundamental concept that underlies genetically mediated similarities among relatives. Gene IBD is traced through ancestral meioses and is defined relative to founders of a pedigree, or to some time point or mutational origin in the coalescent of a set of extant genes in a population. The random process underlying changes in the patterns of IBD across the genome is recombination, so the natural context for defining IBD is the ancestral recombination graph (ARG), which specifies the complete ancestry of a collection of chromosomes. The ARG determines both the sequence of coalescent ancestries across the chromosome and the extant...
Subjects
Medical Subject Headings: digestive system diseases
free text keywords: Review, Genetics, Coalescent theory, Gene, Allele, Biology, Genetic variation, Population, education.field_of_study, education, Genome, Most recent common ancestor, Identity by descent
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