publication . Other literature type . Article . 2001

Resistance-Nodulation-Cell Division-Type Efflux Pump Involved in Aminoglycoside Resistance in Acinetobacter baumannii Strain BM4454

Magnet S; Courvalin P; Lambert T;
Open Access English
  • Published: 01 Dec 2001
  • Publisher: American Society for Microbiology
Abstract
<jats:title>ABSTRACT</jats:title> <jats:p>Multidrug-resistant strain <jats:italic>Acinetobacter baumannii</jats:italic>BM4454 was isolated from a patient with a urinary tract infection. The<jats:italic>adeB</jats:italic> gene, which encodes a resistance-nodulation-cell division (RND) protein, was detected in this strain by PCR with two degenerate oligodeoxynucleotides. Insertional inactivation of<jats:italic>adeB</jats:italic> in BM4454, which generated BM4454-1, showed that the corresponding protein was responsible for aminoglycoside resistance and was involved in the level of susceptibility to other drugs including fluoroquinolones, tetracyclines, chlorampheni...
Subjects
free text keywords: Mechanisms of Resistance, Pharmacology (medical), Pharmacology, Infectious Diseases, Acinetobacter baumannii, biology.organism_classification, biology, Gene expression, Efflux, Microbiology, Membrane transport protein, biology.protein, Ethidium bromide, chemistry.chemical_compound, chemistry, Bacterial outer membrane, Aminoglycoside, Gene cluster
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publication . Other literature type . Article . 2001

Resistance-Nodulation-Cell Division-Type Efflux Pump Involved in Aminoglycoside Resistance in Acinetobacter baumannii Strain BM4454

Magnet S; Courvalin P; Lambert T;