publication . Article . Other literature type . 2007

STAT4 and the Risk of Rheumatoid Arthritis and Systemic Lupus Erythematosus

Remmers, Elaine F.; Plenge, Robert M.; Lee, Annette T.; Graham, Robert R.; Hom, Geoffrey; Behrens, Timothy W.; de Bakker, Paul I.W.; Le, Julie M.; Lee, Hye-Soon; Batliwalla, Franak; ...
Open Access
  • Published: 06 Sep 2007 Journal: New England Journal of Medicine, volume 357, pages 977-986 (issn: 0028-4793, eissn: 1533-4406, Copyright policy)
  • Publisher: Massachusetts Medical Society
Abstract
A SNP haplotype in the third intron of STAT4 was associated with susceptibility to both rheumatoid arthritis and systemic lupus erythematosus. The minor alleles of the haplotype-defining SNPs were present in 27% of chromosomes of patients with established rheumatoid arthritis, as compared with 22% of those of controls (for the SNP rs7574865, P = 2.81×10 −7 ; odds ratio for having the risk allele in chromosomes of patients vs. those of controls, 1.32). The association was replicated in Swedish patients with recent-onset rheumatoid arthritis (P = 0.02) and matched controls. The haplotype marked by rs7574865 was strongly associated with lupus, being present on 31% ...
Subjects
Medical Subject Headings: skin and connective tissue diseases
free text keywords: General Medicine, Case-control study, Allele, Medicine, business.industry, business, Risk factor, Odds ratio, Rheumatoid arthritis, medicine.disease, Lupus erythematosus, Single-nucleotide polymorphism, Systemic lupus erythematosus, Immunology, Intensive care medicine, medicine.medical_specialty, Anti-SSA/Ro autoantibodies, STAT4, Blisibimod, Diabetes mellitus, Dermatology, Article
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