publication . Article . 1997

Quinolone-resistance mutations in the topoisomerase IV parC gene of Acinetobacter baumannii.

J Vila; J Ruiz; P Goñi; T Jimenez de Anta;
Open Access
  • Published: 01 Jun 1997 Journal: Journal of Antimicrobial Chemotherapy, volume 39, pages 757-762 (issn: 0305-7453, eissn: 1460-2091, Copyright policy)
  • Publisher: Oxford University Press (OUP)
Abstract
Mutations in the parC gene, which encodes a subunit of topoisomerase IV, were determined in 21 epidemiologically unrelated clinical isolates of Acinetobacter baumannii. Our studies highlight the conserved sequences in the quinolone-resistance-determining region of the parC gene from A. baumannii and other bacteria. Nine of ten isolates with MICs of ciprofloxacin of ≥32 mg/L showed a change of Ser80 to Leu and one showed a change of Glu84 to Lys. These results suggest that ParC from A. baumannii is a secondary target for quinolones and that mutations at residues Ser80 and Glu84, when combined with mutations at Ser83 of GyrA, may render A. baumannii highly resista...
Subjects
Medical Subject Headings: biochemical phenomena, metabolism, and nutritionbacterial infections and mycosesbacteria
free text keywords: Gene, Acinetobacter baumannii, biology.organism_classification, biology, Virology, Topoisomerase IV, biology.protein, Neisseriaceae, Ciprofloxacin, medicine.drug, medicine, Mutation, medicine.disease_cause, Conserved sequence, Quinolone, medicine.drug_class, Microbiology, Genetics
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publication . Article . 1997

Quinolone-resistance mutations in the topoisomerase IV parC gene of Acinetobacter baumannii.

J Vila; J Ruiz; P Goñi; T Jimenez de Anta;