publication . Other literature type . 2018

A composite score for executive functioning, validated in Alzheimer's Disease Neuroimaging Initiative (ADNI) participants with baseline mild cognitive impairment.

Gibbons, Laura E.; Carle, Adam C.; Mackin, R. Scott; Harvey, Danielle; Mukherjee, Shubhabrata; Insel, Philip; Curtis, S. McKay; Mungas, Dan; Crane, Paul K.; for the Alzheimer’s Disease Neuroimaging Initiative;
  • Published: 13 Nov 2018
The Alzheimer’s Disease Neuroimaging Initiative (ADNI) measures abilities broadly related to executive function (EF), including WAIS-R Digit Symbol Substitution, Digit Span Backwards, Trails A and B, Category Fluency, and Clock Drawing. This study investigates whether a composite executive function measure based on these multiple indicators has better psychometric characteristics than the widely used individual components. We applied item response theory methods to 800 ADNI participants to derive an EF composite score (ADNI-EF) from the above measures. We then compared ADNI-EF with component measures in 390 longitudinally-followed participants with mild cognitiv...
Medical Subject Headings: mental disorders
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