publication . Article . 2016

One-year clinical study of NeuroRegen scaffold implantation following scar resection in complete chronic spinal cord injury patients.

Xiaoxiong Yang; Zhifeng Xiao; Guang Han; Huilin Yang; Yumei Chen; Jianwu Dai; Bing Chen; Jiaguang Tang; Shi-Xiang Cheng; Sai Zhang; ...
Open Access English
  • Published: 22 Jun 2016 Journal: Science China Life Sciences, volume 59, issue 7, pages 647-655 (issn: 1674-7305, Copyright policy)
  • Publisher: Springer Nature
Abstract
The objective of this clinical study was to assess the safety and feasibility of the collagen scaffold, NeuroRegen scaffold, one year after scar tissue resection and implantation. Scar tissue is a physical and chemical barrier that prevents neural regeneration. However, identification of scar tissue is still a major challenge. In this study, the nerve electrophysiology method was used to distinguish scar tissue from normal neural tissue, and then different lengths of scars ranging from 0.5–4.5 cm were surgically resected in five complete chronic spinal cord injury (SCI) patients. The NeuroRegen scaffold along with autologous bone marrow mononuclear cells (BMMCs)...
Subjects
free text keywords: Biochemistry, Genetics and Molecular Biology(all), Agricultural and Biological Sciences(all), Environmental Science(all), General Biochemistry, Genetics and Molecular Biology, General Agricultural and Biological Sciences, General Environmental Science, Scars, medicine.symptom, medicine, Clinical study, Transplantation, Spinal cord injury, medicine.disease, Anatomy, Spinal cord, medicine.anatomical_structure, Somatosensory evoked potential, business.industry, business, Scaffold, Surgery, medicine.medical_specialty, Regeneration (biology)
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