publication . Article . Other literature type . 2013

polyamines and their metabolites as diagnostic markers of human diseases

Park, Myung Hee; Igarashi, Kazuei;
Open Access
  • Published: 31 Jan 2013 Journal: Biomolecules and Therapeutics, volume 21, pages 1-9 (issn: 1976-9148, Copyright policy)
  • Publisher: The Korean Society of Applied Pharmacology
Abstract
Polyamines, putrescine, spermidine and spermine, are ubiquitous in living cells and are essential for eukaryotic cell growth. These polycations interact with negatively charged molecules such as DNA, RNA, acidic proteins and phospholipids and modulate various cellular functions including macromolecular synthesis. Dysregulation of the polyamine pathway leads to pathological conditions including cancer, inflammation, stroke, renal failure and diabetes. Increase in polyamines and polyamine synthesis enzymes is often associated with tumor growth, and urinary and plasma contents of polyamines and their metabolites have been investigated as diagnostic markers for canc...
Subjects
free text keywords: Molecular Medicine, Biochemistry, Pharmacology, Drug Discovery, Catabolism, Spermine, chemistry.chemical_compound, chemistry, Spermidine, Putrescine, Polyamine, Oxidase test, Spermine oxidase, Biology, Metabolite, Articles, Polyamine metabolites, Acrolein, Diacetylspemine, Diagnostic marker, Cancer, Stroke
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