publication . Other literature type . Article . 2007

A Series of 28 Cases

Romain Lazor; Hariharan Regunath;
Open Access
  • Published: 01 May 2007
  • Publisher: Ovid Technologies (Wolters Kluwer Health)
  • Country: France
Abstract
Anti-basement membrane antibody disease is a rare disorder characterized by the presence of autoantibodies binding to the alveolar and glomerular basement membranes, and mediating both alveolar hemorrhage and acute glomerulonephritis. We retrospectively analyzed 28 cases of anti-basement membrane antibody disease with alveolar hemorrhage proven by bronchoalveolar lavage. The median age of patients at diagnosis was 23 years; 68% were male, 89% were active smokers, and 36% were exposed to some other inhaled agent. At diagnosis, 46% had predominant pulmonary involvement with normal initial serum creatinine. Lung function tests disclosed a restrictive ventilatory de...
Subjects
free text keywords: GLOMERULAR BASEMENT-MEMBRANE;NORMAL RENAL-FUNCTION;RECURRENT GOODPASTURES-DISEASE;RAPIDLY PROGRESSIVE GLOMERULONEPHRITIS;OF-THE-LITERATURE;CHEST-X-RAY;WEGENERS GRANULOMATOSIS;PULMONARY HEMORRHAGE;PLASMA-EXCHANGE;IMMUNOSUPPRESSIVE TREATMENT, maladie cardiovasculaire, anticorps, maladie respiratoire, NORMAL RENAL-FUNCTION, RECURRENT GOODPASTURES-DISEASE, RAPIDLY PROGRESSIVE GLOMERULONEPHRITIS, OF-THE-LITERATURE, CHEST-X-RAY, WEGENERS GRANULOMATOSIS, PULMONARY HEMORRHAGE, IMMUNOSUPPRESSIVE TREATMENT, GLOMERULAR BASEMENT-MEMBRANE, PLASMA-EXCHANGE, [SDV]Life Sciences [q-bio], General Medicine
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