publication . Article . Other literature type . 2011

CCR5: from AIDS to atherosclerosis

Janet Maguire; Anthony Peter Davenport;
Open Access
  • Published: 01 Apr 2011 Journal: British Journal of Pharmacology, volume 162, pages 1,453-1,469 (issn: 0007-1188, Copyright policy)
  • Publisher: Wiley
Abstract
There is increasing recognition of an important contribution of chemokines and their receptors in the pathology of atherosclerosis and related cardiovascular disease. The chemokine receptor CCR5 was initially known for its role as a co-receptor for HIV infection of macrophages and is the target of the recently approved CCR5 antagonist maraviroc. However, evidence is now emerging supporting a role for CCR5 and its ligands CCL3 (MIP-1α), CCL4 (MIP-1β) and CCL5 (RANTES) in the initiation and progression of atherosclerosis. Specifically, the CCR5 deletion polymorphism CCR5delta32, which confers resistance to HIV infection, has been associated with a reduced risk of ...
Subjects
Medical Subject Headings: virus diseases
free text keywords: Pharmacology, Reviews
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