publication . Other literature type . Article . 2003

Cell Therapy for Bone Disease: A Review of Current Status

Ranieri Cancedda; Anna Derubeis; Giordano Bianchi; Rodolfo Quarto;
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  • Published: 01 Sep 2003
  • Publisher: Wiley
Abstract
Bone marrow is a reservoir of pluripotent stem/progenitor cells for mesenchymal tissues. Upon in vitro expansion, in vivo bone-forming efficiency of bone marrow stromal cells (BMSCs) is dramatically lower in comparison with fresh bone marrow, and their in vitro multidifferentiation potentials are gradually lost. Nevertheless, when BMSCs are isolated and expanded in the presence of fibroblast growth factor 2, the percentage of cells able to differentiate into the osteogenic, chondrogenic, and adipogenic lineages is greater. Osteogenic progenitors are not exclusive to skeletal tissues. We could also think of cells in different adult tissues as potentially capable ...
Subjects
free text keywords: Developmental Biology, Molecular Medicine, Cell Biology, Stem cell transplantation for articular cartilage repair, Adult stem cell, Stem cell, Mesenchymal stem cell, Anatomy, Progenitor cell, Endothelial stem cell, Bone marrow, medicine.anatomical_structure, medicine, Biology, Clinical uses of mesenchymal stem cells
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