publication . Other literature type . Preprint . Article . 2018

Genome-wide association meta-analysis of cocaine dependence: Shared genetics with comorbid conditions

Cabana-Domínguez, Judit; Shivalikanjli, Anu; Fernàndez-Castillo, Noèlia; Cormand, Bru;
  • Published: 23 Jul 2018
  • Publisher: Elsevier BV
Abstract
<jats:title>Abstract</jats:title><jats:p>Cocaine dependence is a complex psychiatric disorder that is highly comorbid with other psychiatric traits. Twin and adoption studies suggest that genetic variants contribute substantially to cocaine dependence susceptibility, which has an estimated heritability of 65-79%. Here we performed a meta-analysis of genome-wide association studies of cocaine dependence using four datasets from the dbGaP repository (2,085 cases and 4,293 controls, all of them selected by their European ancestry). Although no genome-wide significant hits were found in the SNP-based analysis, the gene-based analysis identified <jats:italic>HIST1H2B...
Subjects
free text keywords: Sample size determination, Cocaine dependence, medicine.disease, medicine, Meta-analysis, SNP, Genome-wide association study, Biology, Genetic association, Single-nucleotide polymorphism, Schizophrenia, Genetics, Biological Psychiatry, Pharmacology, Heritability, Psychology, Major depressive disorder
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NIH| Chronic Renal Insufficiency Cohort Study IV (CRIC-4)
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  • Project Code: 2U01DK060902-18
  • Funding stream: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES
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NIH| Opioid Dependence: Candidate Genes and G x E Effects
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  • Funder: National Institutes of Health (NIH)
  • Project Code: 5R01DA017305-04
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NIH| Chronic Renal Insufficiency Cohort (CRIC) Study
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  • Funder: National Institutes of Health (NIH)
  • Project Code: 3U01DK061022-05S2
  • Funding stream: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES
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NIH| Continuation of the UIC Chronic Renal Insufficiency Cohort Clinical Center
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