publication . Article . 1998

Peak Expiratory Flow Variability, Bronchial Responsiveness, and Susceptibility to Ambient Air Pollution in Adults

Boezen, M.; Schouten, J.; Rijcken, B.; Vonk, J.; Gerritsen, J.; Zee, S.; Hoek, G.; bert brunekreef; Postma, D. S.;
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  • Published: 01 Jan 1998
  • Country: Netherlands
Abstract
Bronchial hyperresponsiveness (BHR) and peak expiratory flow (PEF) variability are associated expressions of airway lability, yet probably reflect different underlying pathophysiologic mechanisms. We investigated whether both measures can be used interchangeably to identify subjects who are susceptible to ambient air pollution. Data on BHR ( ⩾ 20% fall in FEV1), PEF variability (ampl%mean PEF > 5% on any day during an 8-d period with low air pollution levels) and diary data on upper and lower respiratory symptoms, cough, and phlegm were collected in 189 subjects (48–73 yr). The acute effects (lag0) of particulate matter with a diameter less than 10 μ m (PM10), b...
Subjects
Medical Subject Headings: respiratory tract diseasesrespiratory system
free text keywords: Vakgroep Gezondheidsleer, Environmental and Occupational Health Group, Critical Care and Intensive Care Medicine, Pulmonary and Respiratory Medicine
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