publication . Other literature type . Article . 2002

Molecular dissection of hippocampal theta-burst pairing potentiation

Dax Hoffman;
Open Access
  • Published: 21 May 2002
  • Publisher: Proceedings of the National Academy of Sciences
Abstract
Long-term potentiation (LTP) of synaptic efficacy in the hippocampus is frequently induced by tetanic stimulation of presynaptic afferents or by pairing low frequency stimulation with postsynaptic depolarization. Adult (P42) GluR-A(-/-) mice largely lack these forms of LTP. LTP in wt mice can also be induced by coincident pre- and postsynaptic action potentials, where an initial rapid component is expressed but a substantial fraction of the potentiation develops with a delayed time course. We report here that this stimulation protocol, delivered at theta frequency (5 Hz), induces LTP in GluR-A(-/-) mice in which the initial component is substantially reduced. Th...
Subjects
free text keywords: Biological Sciences, Multidisciplinary
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