publication . Article . Other literature type . 1997

Contribution of Autonomic Neuropathy to Reduced Plasma Adrenaline Responses to Hypoglycemia in IDDM: Evidence for a Nonselective Defect

Bottini, P.; Boschetti, E.; Pampanelli, S.; Ciofetta, M.; Sindaco, P. D.; Scionti, L.; Brunetti, P.; Bolli, G. B.;
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  • Published: 01 May 1997 Journal: Diabetes, volume 46, pages 814-823 (issn: 0012-1797, eissn: 0012-1797, Copyright policy)
  • Publisher: American Diabetes Association
Abstract
To determine the contribution of clinically overt diabetic autonomic neuropathy (DAN) to reduced plasma adrenaline responses to hypoglycemia in IDDM and to establish its selectivity for hypoglycemia, we studied 17 IDDM patients (7 without DAN [DAN − ] and 10 with DAN [DAN + ]), of whom 5 had and 5 did not have postural hypotension (DAN + PH + and DAN + PH − , respectively), and 8 nondiabetic subjects on 2 different occasions, i.e., clamped hypoglycemia (steps from 5.0 to 2.2 mmol/l plasma glucose) and 30-min steady-state exercise at 55% VO 2max . Recent antecedent hypoglycemia was meticulously prevented before the studies to exclude hypoglycemia as a cause of re...
Subjects
Medical Subject Headings: nutritional and metabolic diseases
free text keywords: Internal Medicine, Endocrinology, Diabetes and Metabolism, Blood plasma, Glucagon, Diabetes mellitus, medicine.disease, medicine, Epinephrine, medicine.drug, Pancreatic polypeptide, Insulin, medicine.medical_treatment, Endocrinology, medicine.medical_specialty, Hypoglycemia, business.industry, business, Hydrocortisone
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http://dx.doi.org/10.2337/diab...
Other literature type . 1997
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Diabetes
Article . 1997
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Diabetes
Article . 1997
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