publication . Article . Other literature type . 2007

The origins of the developmental origins theory

Barker, D. J. P.;
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  • Published: 01 May 2007 Journal: Journal of Internal Medicine, volume 261, pages 412-417 (issn: 0954-6820, eissn: 1365-2796, Copyright policy)
  • Publisher: Wiley
Abstract
Current orthodoxy states that coronary heart disease results from the unhealthy lifestyles of westernized adults together with a contribution from genetic inheritance. This does not provide a secure basis for prevention of the disease. Geographical studies gave the first clue that the disease originates during intra-uterine development. Variations in mortality from the disease across England and Wales were shown to correlate closely with past differences in death rates among newborn babies. In the past most deaths among newborns were attributed to low birthweight. This led to the hypothesis that undernutrition in utero permanently changes the body's structure, f...
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