publication . Article . Other literature type . 2009

Genetic advances in autism: heterogeneity and convergence on shared pathways.

Bill, Brent R.; Geschwind, Daniel H.;
Open Access
  • Published: 01 Jun 2009 Journal: Current Opinion in Genetics & Development, volume 19, pages 271-278 (issn: 0959-437X, Copyright policy)
  • Publisher: Elsevier BV
Abstract
The autism spectrum disorders (ASD) are a heterogeneous set of developmental disorders characterized at their core by deficits in social interaction and communication. Current psychiatric nosology groups this broad set of disorders with strong genetic liability and multiple etiologies into the same diagnostic category. This heterogeneity has challenged genetic analyses. But shared patient resources, genomic technologies, more refined phenotypes, and novel computational approaches have begun to yield dividends in defining the genetic mechanisms at work. Over the last five years, a large number of autism susceptibility loci have emerged, redefining our notion of a...
Subjects
Medical Subject Headings: mental disordersbehavioral disciplines and activities
free text keywords: Developmental Biology, Genetics, Article
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