publication . Other literature type . Article . 1994

Evidence for a 5-HT4 Receptor Pathway Mediating Chloride Secretion in the Rat Distal Colon

M.R. Budhoo; J.M. Kellum;
  • Published: 01 Jul 1994
  • Publisher: Elsevier BV
Abstract
Abstract Serotonin (5-HT) is a potent secretagogue of chloride ion (Cl - ) and a mediator of diarrhea in the carcinoid syndrome. We investigated the role of the 5-HT 4 receptor pathway in mediating 5-HT-induced Cl - secretion that is seen as a rise in short circuit current ( I SC ) in the Ussing chamber. Rat distal colon was stripped of the muscularis, mounted in Ussing chambers, and short circuited. By cumulative concentration responses, 5-HT-induced rise in I SC was measured in the presence and absence of 0.1 μ M of the nerve conduction blocker, tetrodotoxin (TTX). TTX was later added routinely to remove any effects of residual nerve tissue. 5-HT concentration...
Subjects
free text keywords: Surgery, Methysergide, medicine.drug, medicine, Tetrodotoxin, chemistry.chemical_compound, chemistry, Ussing chamber, Receptor, Internal medicine, medicine.medical_specialty, business.industry, business, 5-HT4 receptor, Endocrinology, Schild regression, Serotonin, Ketanserin
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publication . Other literature type . Article . 1994

Evidence for a 5-HT4 Receptor Pathway Mediating Chloride Secretion in the Rat Distal Colon

M.R. Budhoo; J.M. Kellum;