publication . Article . Other literature type . 2004

Linkage disequilibrium mapping via cladistic analysis of single-nucleotide polymorphism haplotypes.

Caroline Durrant; Krina T. Zondervan; Lon R. Cardon; Sarah Hunt; Panos Deloukas; Andrew P. Morris;
Open Access
  • Published: 01 Jul 2004 Journal: The American Journal of Human Genetics, volume 75, issue 1, pages 35-43 (issn: 0002-9297, Copyright policy)
  • Publisher: Elsevier BV
  • Country: United Kingdom
We present a novel approach to disease-gene mapping via cladistic analysis of single-nucleotide polymorphism (SNP) haplotypes obtained from large-scale, population-based association studies, applicable to whole-genome screens, candidate-gene studies, or fine-scale mapping. Clades of haplotypes are tested for association with disease, exploiting the expected similarity of chromosomes with recent shared ancestry in the region flanking the disease gene. The method is developed in a logistic-regression framework and can easily incorporate covariates such as environmental risk factors or additional unlinked loci to allow for population structure. To evaluate the powe...
free text keywords: Genetics(clinical), Genetics, Articles, Haplotype, Association mapping, Genetic association, Population, education.field_of_study, education, Biology, Single-nucleotide polymorphism, Linkage disequilibrium, Linkage Disequilibrium Mapping, Tag SNP
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