publication . Other literature type . Article . 2006

Stem cell niches in the adult mouse heart

Urbanek, K.; Cesselli, D.; Rota, M.; Nascimbene, A.; De Angelis, A.; Hosoda, T.; Bearzi, C.; Boni, A.; Bolli, R.; Kajstura, J.; ...
Open Access English
  • Published: 05 Jun 2006
  • Publisher: National Academy of Sciences
  • Country: Italy
Abstract
Cardiac stem cells (CSCs) have been identified in the adult heart, but the microenvironment that protects the slow-cycling, undifferentiated, and self-renewing CSCs remains to be determined. We report that the myocardium possesses interstitial structures with the architectural organization of stem cell niches that harbor long-term BrdU-retaining cells. The recognition of long-term label-retaining cells provides functional evidence of resident CSCs in the myocardium, indicating that the heart is an organ regulated by a stem cell compartment. Cardiac niches contain CSCs and lineage-committed cells, which are connected to supporting cells represented by myocytes an...
Subjects
free text keywords: Biological Sciences, Multidisciplinary, Laminin, biology.protein, biology, Integrin, Compartment (ship), Myocyte, Fibronectin, Adherens junction, Cadherin, Stem cell, Cell biology, Diabetes mellitus, medicine.disease, medicine, Bioinformatics, Mouse Heart, business.industry, business, Intensive care medicine, medicine.medical_specialty
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publication . Other literature type . Article . 2006

Stem cell niches in the adult mouse heart

Urbanek, K.; Cesselli, D.; Rota, M.; Nascimbene, A.; De Angelis, A.; Hosoda, T.; Bearzi, C.; Boni, A.; Bolli, R.; Kajstura, J.; ...