publication . Article . 2016

Lipoprotein-Associated Phospholipase A2 Loss-of-Function Variant and Risk of Vascular Diseases in 90,000 Chinese Adults.

Michael Hill; Zheng Bian; Yiping Chen; Stephanie L. Chissoe; Iona Y. Millwood; Richard Peto; Dawn Waterworth; Toby Johnson; Liming Li; Derrick A. Bennett; ...
Open Access
  • Published: 01 Jan 2016 Journal: Journal of the American College of Cardiology, volume 67, issue 2, pages 230-231 (issn: 0735-1097, Copyright policy)
  • Publisher: Elsevier BV
Abstract
Lipoprotein-associated phospholipase A2 (Lp-PLA2) produces the proinflammatory mediators lysophosphatidylcholine and oxidized free fatty acids through hydrolysis of oxidized phospholipids carried on low-density lipoproteins in atherosclerotic plaques. Although increased Lp-PLA2 activity has been associated with higher risks of occlusive vascular diseases, recent phase III trials of the Lp-PLA2 inhibitor darapladib, which reduces Lp-PLA2 activity by ∼60%, failed to establish a protective role of darapladib for prevention of major vascular events in patients with stable coronary heart disease (CHD) or acute coronary syndrome 1, 2.
Subjects
Medical Subject Headings: lipids (amino acids, peptides, and proteins)
free text keywords: Cardiology and Cardiovascular Medicine, Letters, Darapladib, Proinflammatory cytokine, Acute coronary syndrome, medicine.disease, medicine, Endocrinology, medicine.medical_specialty, business.industry, business, Phospholipase A2, biology.protein, biology, Internal medicine, Arterial Occlusive Diseases, Pathology, Lysophosphatidylcholine, chemistry.chemical_compound, chemistry, 1-Alkyl-2-acetylglycerophosphocholine Esterase, Lipoprotein-associated phospholipase A2

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