publication . Article . 2013

Comparison between PET template-based method and MRI-based method for cortical quantification of florbetapir (AV-45) uptake in vivo.

Saint-Aubert, L.; Nemmi, F.; Péran, P.; Barbeau, E. J.; Payoux, P.; Chollet, F.; Pariente, J.;
Open Access English
  • Published: 01 Jan 2013
  • Publisher: HAL CCSD
Abstract
Purpose Florbetapir (AV-45) has been shown to be a reliable tool for assessing in vivo amyloid load in patients with Alzheimer’s disease from the early stages. However, nonspecific white matter binding has been reported in healthy subjects as well as in patients with Alzheimer’s disease. To avoid this issue, cortical quantification might increase the reliability of AV-45 PET analyses. In this study, we compared two quantification methods for AV-45 binding, a classical method relying on PET template registration (route 1), and a MRI-based method (route 2) for cortical quantification. Methods We recruited 22 patients at the prodromal stage of Alzheimer’s disease a...
Subjects
free text keywords: [SCCO.NEUR]Cognitive science/Neuroscience, Radiology Nuclear Medicine and imaging, Original Article, Alzheimer’s disease, Florbetapir, Amyloid, PET imaging, Cortex, General Medicine, Nuclear medicine, business.industry, business, In vivo, Positron emission tomography, medicine.diagnostic_test, medicine, Pathology, medicine.medical_specialty, Magnetic resonance imaging, Alzheimer's disease, medicine.disease, White matter, medicine.anatomical_structure
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publication . Article . 2013

Comparison between PET template-based method and MRI-based method for cortical quantification of florbetapir (AV-45) uptake in vivo.

Saint-Aubert, L.; Nemmi, F.; Péran, P.; Barbeau, E. J.; Payoux, P.; Chollet, F.; Pariente, J.;