publication . Article . Other literature type . 2003

The endogenous cannabinoid system affects energy balance via central orexigenic drive and peripheral lipogenesis

Cota, Daniela; Marsicano, Giovanni; Tschöp, Matthias; Grübler, Yvonne; Flachskamm, Cornelia; Schubert, Mirjam; Auer, Dorothee; Yassouridis, Alexander; Thöne-Reineke, Christa; Ortmann, Sylvia; ...
Open Access
  • Published: 01 Aug 2003 Journal: Journal of Clinical Investigation, volume 112, pages 423-431 (issn: 0021-9738, Copyright policy)
  • Publisher: American Society for Clinical Investigation
Abstract
The cannabinoid receptor type 1 (CB1) and its endogenous ligands, the endocannabinoids, are involved in the regulation of food intake. Here we show that the lack of CB1 in mice with a disrupted CB1 gene causes hypophagia and leanness. As compared with WT (CB1+/+) littermates, mice lacking CB1 (CB1–/–) exhibited reduced spontaneous caloric intake and, as a consequence of reduced total fat mass, decreased body weight. In young CB1–/– mice, the lean phenotype is predominantly caused by decreased caloric intake, whereas in adult CB1–/– mice, metabolic factors appear to contribute to the lean phenotype. No significant differences between genotypes were detected regar...
Subjects
Medical Subject Headings: nervous systemlipids (amino acids, peptides, and proteins)musculoskeletal, neural, and ocular physiologypsychological phenomena and processesmental disorders
free text keywords: General Medicine, Cannabinoid receptor type 1, Corticotropin-releasing hormone, Lipogenesis, Energy homeostasis, Internal medicine, medicine.medical_specialty, medicine, Endocannabinoid system, Biology, Cannabinoid receptor, Appetite, media_common.quotation_subject, media_common, Biochemistry, Endocrinology, Orexigenic, medicine.drug, Article
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publication . Article . Other literature type . 2003

The endogenous cannabinoid system affects energy balance via central orexigenic drive and peripheral lipogenesis

Cota, Daniela; Marsicano, Giovanni; Tschöp, Matthias; Grübler, Yvonne; Flachskamm, Cornelia; Schubert, Mirjam; Auer, Dorothee; Yassouridis, Alexander; Thöne-Reineke, Christa; Ortmann, Sylvia; ...