publication . Article . Other literature type . 1994

Tolerance, Danger, and the Extended Family

P, Matzinger;
Open Access
  • Published: 01 Apr 1994 Journal: Annual Review of Immunology, volume 12, pages 991-1,045 (issn: 0732-0582, Copyright policy)
  • Publisher: Annual Reviews
For many years immunologists have been well served by the viewpoint that the immune system's primary goal is to discriminate between self and non-self. I believe that it is time to change viewpoints and, in this essay, I discuss the possibility that the immune system does not care about self and non-self, that its primary driving force is the need to detect and protect against danger, and that it does not do the job alone, but receives positive and negative communications from an extended network of other bodily tissues.
Medical Subject Headings: educationhumanities
free text keywords: Immunology, Immunology and Allergy
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