publication . Article . Other literature type . 2014

A synthetic sex ratio distortion system for the control of the human malaria mosquito

Galizi, Roberto; Doyle, Lindsey A.; Menichelli, Miriam; Bernardini, Federica; Deredec, Anne; Burt, Austin; Stoddard, Barry L.; Windbichler, Nikolai; Crisanti, Andrea;
Open Access English
  • Published: 10 Jun 2014
Abstract
Extreme reproductive sex ratios could result in the suppression or elimination of pest populations. Here, the authors design a synthetic sex distortion system in Anopheles gambiae that gives rise to fertile mosquito strains that produce over 95% male offsprings and could therefore be used to suppress mosquito populations.
Subjects
Medical Subject Headings: parasitic diseases
free text keywords: Genetic engineering;homing endonuclease;Anopheles gambiae;vector control, Genetic engineering, homing endonuclease, Anopheles gambiae, vector control, [SDV]Life Sciences [q-bio], [SDE]Environmental Sciences, Article, Q1, QL, SF, Science & Technology, Multidisciplinary Sciences, Science & Technology - Other Topics, ENCODED HOMING ENDONUCLEASE, PHYSARUM-POLYCEPHALUM, AEDES-AEGYPTI, MEIOTIC DRIVE, PEST-CONTROL, I-PPOI, INTRON, DNA, MANIPULATION, Animals, Animals, Genetically Modified, Female, Insect Vectors, Malaria, Male, Sex Ratio, MD Multidisciplinary, General Biochemistry, Genetics and Molecular Biology, General Physics and Astronomy, General Chemistry, biology.protein, biology, X chromosome, Aedes aegypti, biology.organism_classification, Molecular genetics, medicine.medical_specialty, medicine, Mosquito control, Genetics, Vector (epidemiology), Gene drive
Funded by
EC| VECSYN
Project
VECSYN
Synthetic species of the mosquito vectors of human disease: from hybrid genetics to a new type of vector control
  • Funder: European Commission (EC)
  • Project Code: 335724
  • Funding stream: FP7 | SP2 | ERC

We thank Eric Marois, Silke Fuchs, Tony Nolan, Ann Hall, Andrew Hammond and Shani Jayawardhan. This study was funded by a grant from the Foundation for the National Institutes of Health through the Vector-Based Control of Transmission: Discovery Research (VCTR) programme of the Grand Challenges in Global Health initiative of the Bill & Melinda Gates Foundation. This study was funded by the European Research Council under the European Union's Seventh Framework Programme ERC grant no. 335724 awarded to N.W. Funded by the European Commission and Regione Umbria under grant agreement I-MOVE-PCOFUND-GA-2010-267332.

Abstract
Extreme reproductive sex ratios could result in the suppression or elimination of pest populations. Here, the authors design a synthetic sex distortion system in Anopheles gambiae that gives rise to fertile mosquito strains that produce over 95% male offsprings and could therefore be used to suppress mosquito populations.
Subjects
Medical Subject Headings: parasitic diseases
free text keywords: Genetic engineering;homing endonuclease;Anopheles gambiae;vector control, Genetic engineering, homing endonuclease, Anopheles gambiae, vector control, [SDV]Life Sciences [q-bio], [SDE]Environmental Sciences, Article, Q1, QL, SF, Science & Technology, Multidisciplinary Sciences, Science & Technology - Other Topics, ENCODED HOMING ENDONUCLEASE, PHYSARUM-POLYCEPHALUM, AEDES-AEGYPTI, MEIOTIC DRIVE, PEST-CONTROL, I-PPOI, INTRON, DNA, MANIPULATION, Animals, Animals, Genetically Modified, Female, Insect Vectors, Malaria, Male, Sex Ratio, MD Multidisciplinary, General Biochemistry, Genetics and Molecular Biology, General Physics and Astronomy, General Chemistry, biology.protein, biology, X chromosome, Aedes aegypti, biology.organism_classification, Molecular genetics, medicine.medical_specialty, medicine, Mosquito control, Genetics, Vector (epidemiology), Gene drive
Funded by
EC| VECSYN
Project
VECSYN
Synthetic species of the mosquito vectors of human disease: from hybrid genetics to a new type of vector control
  • Funder: European Commission (EC)
  • Project Code: 335724
  • Funding stream: FP7 | SP2 | ERC

We thank Eric Marois, Silke Fuchs, Tony Nolan, Ann Hall, Andrew Hammond and Shani Jayawardhan. This study was funded by a grant from the Foundation for the National Institutes of Health through the Vector-Based Control of Transmission: Discovery Research (VCTR) programme of the Grand Challenges in Global Health initiative of the Bill & Melinda Gates Foundation. This study was funded by the European Research Council under the European Union's Seventh Framework Programme ERC grant no. 335724 awarded to N.W. Funded by the European Commission and Regione Umbria under grant agreement I-MOVE-PCOFUND-GA-2010-267332.

Powered by OpenAIRE Research Graph
Any information missing or wrong?Report an Issue