publication . Article . Other literature type . 2005

prevalence and patterns of cognitive impairment in sporadic als

Ringholz, G. M.; Appel, S. H.; Bradshaw, M.; Cooke, N. A.; Mosnik, D. M.; Schulz, P. E.;
  • Published: 22 Aug 2005 Journal: Neurology, volume 65, pages 586-590 (issn: 0028-3878, eissn: 1526-632X, Copyright policy)
  • Publisher: Ovid Technologies (Wolters Kluwer Health)
Objective: To investigate the prevalence and nature of cognitive changes associated with sporadic amyotrophic lateral sclerosis (ALS) using a large scale study. Methods: Consecutive patients with sporadic ALS (n = 279) underwent comprehensive neurologic evaluation and neuropsychological testing. Testing data from normal controls (n = 129) were used for classification and comparison purposes. Results: On non-motor, non-speed-dependent tasks, 51% of patients with ALS had evidence of cognitive impairment compared to 5% of controls. Cluster analysis suggested four patient subgroups: 49% intact, 32% with mild impairment, 13% with moderate impairment, and 6% with seve...
free text keywords: Clinical Neurology, Internal medicine, medicine.medical_specialty, medicine, business.industry, business, Executive dysfunction, Physical therapy, Alzheimer's disease, medicine.disease, Amyotrophic lateral sclerosis, Cross-sectional study, Comorbidity, Dementia, Cognitive disorder, Frontotemporal dementia, Psychiatry
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