publication . Other literature type . Article . 2011

Exome Sequencing of Head and Neck Squamous Cell Carcinoma Reveals Inactivating Mutations in NOTCH1

N. Agrawal; M. J. Frederick; C. R. Pickering; C. Bettegowda; K. Chang; R. J. Li; C. Fakhry; T.-X. Xie; J. Zhang; J. Wang; ...
Open Access English
  • Published: 28 Jul 2011
Abstract
Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer worldwide. To explore the genetic origins of this cancer, we used whole-exome sequencing and gene copy number analyses to study 32 primary tumors. Tumors from patients with a history of tobacco use had more mutations than did tumors from patients who did not use tobacco, and tumors that were negative for human papillomavirus (HPV) had more mutations than did HPV-positive tumors. Six of the genes that were mutated in multiple tumors were assessed in up to 88 additional HNSCCs. In addition to previously described mutations in TP53 , CDKN2A , PIK3CA , and HRAS , we identified mutations in...
Subjects
free text keywords: Article, Multidisciplinary, CDKN2A, Tumor suppressor gene, HRAS, Exome sequencing, Gene dosage, Genetics, Cancer, medicine.disease, medicine, Cancer research, Head and neck squamous-cell carcinoma, Mutation, medicine.disease_cause, Biology
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Other literature type . 2011
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Article . 2011
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