publication . Other literature type . Article . 2011

Impulse control: Temporal dynamics in gene transcription

Nir Yosef; Aviv Regev; Aviv Regev;
Open Access
  • Published: 01 Mar 2011
  • Publisher: Elsevier BV
Regulatory circuits controlling gene expression constantly rewire to adapt to environmental stimuli, differentiation cues, and disease. We review our current understanding of the temporal dynamics of gene expression in eukaryotes and prokaryotes and the molecular mechanisms that shape them. We delineate several prototypical temporal patterns, including “impulse” (or single-pulse) patterns in response to transient environmental stimuli, sustained (or state-transitioning) patterns in response to developmental cues, and oscillating patterns. We focus on impulse responses and their higher-order temporal organization in regulons and cascades and describe how core pro...
free text keywords: Article, General Biochemistry, Genetics and Molecular Biology, Biochemistry, Genetics and Molecular Biology(all), Regulon, Neuroscience, Promoter, Regulatory sequence, Regulation of gene expression, Biology, Gene expression, Transcription factor, Genetics, Chromatin, Impulse control
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