publication . Other literature type . Article . 2011

Impulse control: Temporal dynamics in gene transcription

Name: Impulse control: Temporal dynamics in gene transcription
Keywords: Article, General Biochemistry, Genetics and Molecular Biology, Biochemistry, Genetics and Molecular Biology(all)

Nir Yosef; Aviv Regev; Aviv Regev;

Open Access

Published: 01 Mar 2011

Publisher: Elsevier BV

Summary

Abstract

Regulatory circuits controlling gene expression constantly rewire to adapt to environmental stimuli, differentiation cues, and disease. We review our current understanding of the temporal dynamics of gene expression in eukaryotes and prokaryotes and the molecular mechanisms that shape them. We delineate several prototypical temporal patterns, including “impulse” (or single-pulse) patterns in response to transient environmental stimuli, sustained (or state-transitioning) patterns in response to developmental cues, and oscillating patterns. We focus on impulse responses and their higher-order temporal organization in regulons and cascades and describe how core pro...

doi: 10.1016/j.cell.2011.02.015

pmc: PMC3148525

pmid: 21414481

Subjects

free text keywords: Article, General Biochemistry, Genetics and Molecular Biology, Biochemistry, Genetics and Molecular Biology(all), Regulon, Neuroscience, Promoter, Regulatory sequence, Regulation of gene expression, Biology, Gene expression, Transcription factor, Genetics, Chromatin, Impulse control

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