publication . Other literature type . Article . 2006

CSF phosphorylated tau protein correlates with neocortical neurofibrillary pathology in Alzheimer's disease

K. Buerger; M. Ewers; T. Pirttila; R. Zinkowski; I. Alafuzoff; S. J. Teipel; J. DeBernardis; D. Kerkman; C. McCulloch; H. Soininen; ...
  • Published: 29 Sep 2006
  • Publisher: Oxford University Press (OUP)
Hyperphosphorylated tau protein (P-tau) in CSF is a core biomarker candidate of Alzheimer's disease. Hyperphosphorylation of tau is thought to lead to neurofibrillary changes, a neuropathological hallmark of this type of dementia. Currently, the question is unresolved whether CSF levels of P-tau reflect neurofibrillary changes within the brain of a patient with the illness. Twenty-six patients were included with intra-vitam CSF as well as post-mortem neuropathological data. In the CSF, P-tau phosphorylated at threonine 231 (P-tau231P) was analysed. Post-mortem, scores of neurofibrillary tangles (NFT) and neuritic plaques (NP) were assessed in frontal, temporal, ...
Medical Subject Headings: mental disorders
free text keywords: Clinical Neurology, Cerebrospinal fluid, Medicine, business.industry, business, Tau protein, biology.protein, biology, Alzheimer's disease, medicine.disease, Neuropathology, Frontal lobe, Senile plaques, Neuroscience, Hyperphosphorylation, Pathology, medicine.medical_specialty, Hippocampus
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Article . 2006
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Other literature type . 2006
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