publication . Article . Other literature type . 2004

Possible Contribution of Endoplasmic Reticulum Stress to Cardiac Myocyte Apoptosis

Okada, Ken-ichiro; Minamino, Tetsuo; Tsukamoto, Yoshitane; Liao, Yulin; Tsukamoto, Osamu; Takashima, Seiji; Hirata, Akio; Fujita, Masashi; Nagamachi, Yoko; Nakatani, Takeshi; ...
Open Access
  • Published: 10 Aug 2004 Journal: Circulation, volume 110, pages 705-712 (issn: 0009-7322, eissn: 1524-4539, Copyright policy)
  • Publisher: Ovid Technologies (Wolters Kluwer Health)
Background— The endoplasmic reticulum (ER) is recognized as an organelle that participates in folding secretory and membrane proteins. The ER responds to stress by upregulating ER chaperones, but prolonged and/or excess ER stress leads to apoptosis. However, the potential role of ER stress in pathophysiological hearts remains unclear. Methods and Results— Mice were subjected to transverse aortic constriction (TAC) or sham operation. Echocardiographic analysis demonstrated that mice 1 and 4 weeks after TAC had cardiac hypertrophy and failure, respectively. Cardiac expression of ER chaperones was significantly increased 1 and 4 weeks after TAC, indicating that pre...
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Other literature type . 2004
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Article . 2004
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