publication . Other literature type . Article . 2005

Myocardial ischemia/reperfusion-injury, a clinical view on a complex pathophysiological process

Marc Claeys;
  • Published: 01 Apr 2005
  • Publisher: Elsevier BV
  • Country: Belgium
Abstract
Abstract Myocardial infarction is the major cause of death in the world. Over the last two decades, coronary reperfusion therapy has become established for the management of acute myocardial infarction (AMI). However, restoration of blood flow to previously ischemic myocardium results in the so-called ischemia/reperfusion (IR)-injury. The different clinical manifestations of this injury include myocardial necrosis, arrhythmia, myocardial stunning and endothelial- and microvascular dysfunction including the no-reflow phenomenon. The pathogenesis of ischemia/reperfusion injury consists of many mechanisms. Recently, there's increasing evidence for an important role...
Subjects
free text keywords: Endothelial dysfunction, medicine.disease, medicine, Myocardial infarction, Internal medicine, medicine.medical_specialty, Cariporide, chemistry.chemical_compound, chemistry, Reperfusion therapy, Cardiology, Ischemia, Reperfusion injury, Myocardial stunning, Trimetazidine, medicine.drug, business.industry, business
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