publication . Article . Other literature type . 2015

Global circulation patterns of seasonal influenza viruses vary with antigenic drift.

Varsha Potdar; Colin A. Russell; Nicola S. Lewis; Masato Tashiro; Aeron C. Hurt; Philippe Lemey; Xiyan Li; Dayan Wang; Anne Kelso; C. Palani Gunasekaran; ...
Open Access English
  • Published: 01 Jul 2015
  • Publisher: NPG
Abstract
Understanding the spatio‐temporal patterns of emergence and circulation of new human seasonal influenza virus variants is a key scientific and public health challenge. The global circulation patterns of influenza A/H3N2 viruses are well- characterized1‐7 but the patterns of A/H1N1 and B viruses have remained largely unexplored. Here, based on analyses of 9,604 hemagglutinin sequences of human seasonal influenza viruses from 2000–2012, we show that the global circulation patterns of A/H1N1 (up to 2009), B/Victoria, and B/Yamagata viruses differ substantially from those of A/H3N2 viruses. While genetic variants of A/H3N2 viruses did not persist locally between epi...
Subjects
free text keywords: Humans, Influenza A virus, Influenza B virus, Seasons, Age Factors, Phylogeny, Antigenic Variation, Influenza, Human, Phylogeography, Global Health, General Science & Technology, Article, Virology, Virus, Antigenic drift, medicine.disease_cause, medicine, Viral evolution, Zoology, Phylogenetics, Biology
Funded by
NIH| Ecology of Infectious Diseases (EID)-Immune Landscapes of Human Influenza in Hous
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 5R01TW008246-02
  • Funding stream: FOGARTY INTERNATIONAL CENTER
,
EC| PREDEMICS
Project
PREDEMICS
Preparedness, Prediction and Prevention of Emerging Zoonotic Viruses with Pandemic Potential using Multidisciplinary Approaches
  • Funder: European Commission (EC)
  • Project Code: 278433
  • Funding stream: FP7 | SP1 | HEALTH
,
NSF| Advancing the Molecular Epidemiology of Infectious Diseases through Bayesian Phylogenetics
Project
  • Funder: National Science Foundation (NSF)
  • Project Code: 1264153
  • Funding stream: Directorate for Mathematical & Physical Sciences | Division of Mathematical Sciences
,
WT| Merging theory and field studies for infectious disease dynamics.
Project
  • Funder: Wellcome Trust (WT)
  • Project Code: 093488
  • Funding stream: Immune System in Health and Disease
,
NIH| Models for synthesising molecular, clinical and epidemiological data, and transla
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 1U01GM110721-01
  • Funding stream: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
41 references, page 1 of 3

Russell, CA. The global circulation of seasonal influenza A (H3N2) viruses. Science. 2008; 320: 340-346 [PubMed]

Lemey, P. Unifying viral genetics and human transportation data to predict the global transmission dynamics of human influenza H3N2. PLoS Pathog. 2014; 10: e1003932 [OpenAIRE] [PubMed]

Rambaut, A. The genomic and epidemiological dynamics of human influenza A virus. Nature. 2008; 453: 615-619 [OpenAIRE] [PubMed]

Bedford, T, Cobey, S, Beerli, P, Pascual, M. Global migration dynamics underlie evolution and persistence of human influenza A (H3N2). PLoS Pathog. 2010; 6: e1000918 [OpenAIRE] [PubMed]

Chan, J, Holmes, A, Rabadan, R. Network analysis of global influenza spread. PLoS Comput Biol. 2010; 6: e1001005 [OpenAIRE] [PubMed]

Nelson, MI, Simonsen, L, Viboud, C, Miller, MA, Holmes, EC. Phylogenetic analysis reveals the global migration of seasonal influenza A viruses. PLoS Pathog. 2007; 3: 1220-1228 [OpenAIRE] [PubMed]

Nelson, MI. Stochastic processes are key determinants of short-term evolution in influenza a virus. PLoS Pathog. 2006; 2: e125 [OpenAIRE] [PubMed]

Glezen, PW, Schmier, JK, Kuehn, CM, Ryan, KJ, Oxford, J. The burden of influenza B: a structured literature review. Am J Public Health. 2013; 103: e43-51 [OpenAIRE]

Thompson, WW. Influenza-associated hospitalizations in the United States. Jama. 2004; 292: 1333-1340 [PubMed]

Squires, RB. Influenza research database: an integrated bioinformatics resource for influenza research and surveillance. Influenza Other Respir Viruses. 2012; 6: 404-416 [OpenAIRE] [PubMed]

Chen, R, Holmes, EC. The evolutionary dynamics of human influenza B virus. J Mol Evol. 2008; 66: 655-663 [OpenAIRE] [PubMed]

Cox, NJ, Bender, CA. The molecular epidemiology of influenza viruses. Seminars in Virology. 1995; 6: 359-370

Bedford, T. Integrating influenza antigenic dynamics with molecular evolution. eLife. 2014; 3: e01914 [OpenAIRE] [PubMed]

Bedford, T, Cobey, S, Pascual, M. Strength and tempo of selection revealed in viral gene genealogies. BMC Evol Biol. 2011; 11: 220 [OpenAIRE] [PubMed]

Lemey, P, Rambaut, A, Drummond, AJ, Suchard, MA. Bayesian phylogeography finds its roots. PLoS Comput Biol. 2009; 5: e1000520 [OpenAIRE] [PubMed]

41 references, page 1 of 3
Abstract
Understanding the spatio‐temporal patterns of emergence and circulation of new human seasonal influenza virus variants is a key scientific and public health challenge. The global circulation patterns of influenza A/H3N2 viruses are well- characterized1‐7 but the patterns of A/H1N1 and B viruses have remained largely unexplored. Here, based on analyses of 9,604 hemagglutinin sequences of human seasonal influenza viruses from 2000–2012, we show that the global circulation patterns of A/H1N1 (up to 2009), B/Victoria, and B/Yamagata viruses differ substantially from those of A/H3N2 viruses. While genetic variants of A/H3N2 viruses did not persist locally between epi...
Subjects
free text keywords: Humans, Influenza A virus, Influenza B virus, Seasons, Age Factors, Phylogeny, Antigenic Variation, Influenza, Human, Phylogeography, Global Health, General Science & Technology, Article, Virology, Virus, Antigenic drift, medicine.disease_cause, medicine, Viral evolution, Zoology, Phylogenetics, Biology
Funded by
NIH| Ecology of Infectious Diseases (EID)-Immune Landscapes of Human Influenza in Hous
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 5R01TW008246-02
  • Funding stream: FOGARTY INTERNATIONAL CENTER
,
EC| PREDEMICS
Project
PREDEMICS
Preparedness, Prediction and Prevention of Emerging Zoonotic Viruses with Pandemic Potential using Multidisciplinary Approaches
  • Funder: European Commission (EC)
  • Project Code: 278433
  • Funding stream: FP7 | SP1 | HEALTH
,
NSF| Advancing the Molecular Epidemiology of Infectious Diseases through Bayesian Phylogenetics
Project
  • Funder: National Science Foundation (NSF)
  • Project Code: 1264153
  • Funding stream: Directorate for Mathematical & Physical Sciences | Division of Mathematical Sciences
,
WT| Merging theory and field studies for infectious disease dynamics.
Project
  • Funder: Wellcome Trust (WT)
  • Project Code: 093488
  • Funding stream: Immune System in Health and Disease
,
NIH| Models for synthesising molecular, clinical and epidemiological data, and transla
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 1U01GM110721-01
  • Funding stream: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
41 references, page 1 of 3

Russell, CA. The global circulation of seasonal influenza A (H3N2) viruses. Science. 2008; 320: 340-346 [PubMed]

Lemey, P. Unifying viral genetics and human transportation data to predict the global transmission dynamics of human influenza H3N2. PLoS Pathog. 2014; 10: e1003932 [OpenAIRE] [PubMed]

Rambaut, A. The genomic and epidemiological dynamics of human influenza A virus. Nature. 2008; 453: 615-619 [OpenAIRE] [PubMed]

Bedford, T, Cobey, S, Beerli, P, Pascual, M. Global migration dynamics underlie evolution and persistence of human influenza A (H3N2). PLoS Pathog. 2010; 6: e1000918 [OpenAIRE] [PubMed]

Chan, J, Holmes, A, Rabadan, R. Network analysis of global influenza spread. PLoS Comput Biol. 2010; 6: e1001005 [OpenAIRE] [PubMed]

Nelson, MI, Simonsen, L, Viboud, C, Miller, MA, Holmes, EC. Phylogenetic analysis reveals the global migration of seasonal influenza A viruses. PLoS Pathog. 2007; 3: 1220-1228 [OpenAIRE] [PubMed]

Nelson, MI. Stochastic processes are key determinants of short-term evolution in influenza a virus. PLoS Pathog. 2006; 2: e125 [OpenAIRE] [PubMed]

Glezen, PW, Schmier, JK, Kuehn, CM, Ryan, KJ, Oxford, J. The burden of influenza B: a structured literature review. Am J Public Health. 2013; 103: e43-51 [OpenAIRE]

Thompson, WW. Influenza-associated hospitalizations in the United States. Jama. 2004; 292: 1333-1340 [PubMed]

Squires, RB. Influenza research database: an integrated bioinformatics resource for influenza research and surveillance. Influenza Other Respir Viruses. 2012; 6: 404-416 [OpenAIRE] [PubMed]

Chen, R, Holmes, EC. The evolutionary dynamics of human influenza B virus. J Mol Evol. 2008; 66: 655-663 [OpenAIRE] [PubMed]

Cox, NJ, Bender, CA. The molecular epidemiology of influenza viruses. Seminars in Virology. 1995; 6: 359-370

Bedford, T. Integrating influenza antigenic dynamics with molecular evolution. eLife. 2014; 3: e01914 [OpenAIRE] [PubMed]

Bedford, T, Cobey, S, Pascual, M. Strength and tempo of selection revealed in viral gene genealogies. BMC Evol Biol. 2011; 11: 220 [OpenAIRE] [PubMed]

Lemey, P, Rambaut, A, Drummond, AJ, Suchard, MA. Bayesian phylogeography finds its roots. PLoS Comput Biol. 2009; 5: e1000520 [OpenAIRE] [PubMed]

41 references, page 1 of 3
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